Modafinil attenuates the neuroinflammatory response after experimental traumatic brain injury

Ozturk, Yasar; Bozkurt, İsmail; Güvenç, Yahya; Kepoğlu, Ümit; Cingirt, Mehmet; Gülbahar, Özlem; Özçerezci, Tuğba; Şentürk, Salim; Yaman, Mesut Emre

doi:10.23736/s0390-5616.21.05382-0

Cited by 4 publications

(1 citation statement)

References 26 publications

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“…Wake-promoting agents have shown some success in ameliorating excessive sleepiness after TBI ( Kaiser et al, 2010 ; Menn et al, 2014 ), while stimulants have been less studied in the clinical setting. In a preclinical model of TBI, modafinil attenuates neuroinflammation and exerts neuroprotective effects ( Ozturk et al, 2021 ). These anti-inflammatory actions may underlie the effectiveness of modafinil in treating excessive daytime sleepiness after a brain injury.…”

Section: Treating Tbi-induced Sleep Disturbancesmentioning

confidence: 99%

Sleep, inflammation, and hemodynamics in rodent models of traumatic brain injury

Green,

Carey,

Mannino

et al. 2024

Front. Neurosci.

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Traumatic brain injury (TBI) can induce dysregulation of sleep. Sleep disturbances include hypersomnia and hyposomnia, sleep fragmentation, difficulty falling asleep, and altered electroencephalograms. TBI results in inflammation and altered hemodynamics, such as changes in blood brain barrier permeability and cerebral blood flow. Both inflammation and altered hemodynamics, which are known sleep regulators, contribute to sleep impairments post-TBI. TBIs are heterogenous in cause and biomechanics, which leads to different molecular and symptomatic outcomes. Animal models of TBI have been developed to model the heterogeneity of TBIs observed in the clinic. This review discusses the intricate relationship between sleep, inflammation, and hemodynamics in pre-clinical rodent models of TBI.

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Section: Treating Tbi-induced Sleep Disturbancesmentioning

confidence: 99%