Abstract. Let M n be an immersed umbilic-free hypersurface in the (n + 1)-dimensional unit sphere S n+1 , then M n is associated with a so-called Möbius metric g, a Möbius second fundamental form B and a Möbius form Φ which are invariants of M n under the Möbius transformation group of S n+1 . A classical theorem of Möbius geometry states that M n (n ≥ 3) is in fact characterized by g and B up to Möbius equivalence. A Möbius isoparametric hypersurface is defined by satisfying two conditions: (1) Φ ≡ 0; (2) All the eigenvalues of B with respect to g are constants. Note that Euclidean isoparametric hypersurfaces are automatically Möbius isoparametric, whereas the latter are Dupin hypersurfaces.In this paper, we prove that a Möbius isoparametric hypersurface in S 4 is either of parallel Möbius second fundamental form or Möbius equivalent to a tube of constant radius over a standard Veronese embedding of RP 2 into S 4 . The classification of hypersurfaces in S n+1 (n ≥ 2) with parallel Möbius second fundamental form has been accomplished in our previous paper [6]. The present result is a counterpart of Pinkall's classification for Dupin hypersurfaces in E 4 up to Lie equivalence. §1. Introduction Let x : M n → S n+1 be a hypersurface in the (n + 1)-dimensional unit sphere S n+1 without umbilic point and {e i } be a local orthonormal basis with respect to the induced metric I = dx · dx with dual basis {θ i }. Let II = i,j h ij θ i ⊗ θ j be the second fundamental form with length square II 2 = i,j (h ij ) 2 and H = 1 n i h ii the mean curvature of x, respectively. Define ρ 2 = n/(n − 1) · ( II 2 − nH 2 ), then the positive definite form g = ρ 2 dx · dx is a Möbius invariant and is called the Möbius metric of x : M n → S n+1 . The Möbius second fundamental form B, another basic Möbius invariant of x, together with g determine completely a hypersurface of S n+1 up to Möbius equivalence, see Theorem 2.2 below. vanishes and all eigenvalues w.r.t. g of the Möbius shape operatorare constant, here S denotes the shape operator of x : M n → S n+1 . This definition of Möbius isoparametric hypersurfaces is meaningful when we compared it with that of (Euclidean) isoparametric hypersurfaces in S n+1 , as we see that the images of all hypersurfaces of the sphere with constant mean curvature and constant scalar curvature under Möbius transformation satisfy Φ ≡ 0 and that the Möbius invariant operator S play the same role in Möbius geometry as S does in the Euclidean situation (see with γ = 2. In this paper, by relaxing the restriction of γ = 2, we will consider Möbius isoparametric hypersurfaces of S 4 and finally determine all of them in explicit form. To state the result, we first recall that for the n-dimensional hyperbolic space of constant sectional curvature −c < 0and the hemisphere S n + = (x 1 , . . . , x n+1 ) ∈ S n i x 2 i = 1, x 1 > 0 , we can define, respectively, the conformal diffeomorphism σ : R n → S n \ (1) the torus S k (a) × S 3−k (b) with k = 1, 2 and a 2 + b 2 = 1;(2) the image of σ of the standard cylinder S k...