Mobilization of CD34+, CD117+, CXCR4+, c-met+ stem cells is correlated with left ventricular ejection fraction and plasma NT-proBNP levels in patients with acute myocardial infarction

Abstract

The mobilization of CD34(+), CD117(+), CXCR4(+), c-met(+) stem cells into peripheral blood early in STEMI is positively correlated with LVEF and negatively correlated with NT-proBNP levels and myocardial necrosis markers.

Bone marrow-derived pluripotent very small embryonic-like stem cells (VSELs) are mobilized after acute myocardial infarction

“…These include hematopoietic stem cells [29,30], mesenchymal stem cells [31], endothelial progenitor cells [29,32], and other distinct subpopulations characterized by surface markers. Circulating CD34 + progenitors [30,33] and CD34+/CXCR4+, CD34+/c-kit+, c-met+ subpopulations [34,35] have been observed in patients after an acute MI. Studies in animals have shown the presence of BM-derived c-kit+, CD31+ cells in the infarcted myocardium after MI [36].…”

An underlying principle for the study of circulating progenitor cells in diabetes and its complications

“…To further complicate this picture, the tyrosine kinase receptor CD117 (c-kit) is also expressed on tissue-resident stem/ progenitor cells, and these cells may be found in the bloodstream as the result of an equilibrium between the circulation and tissue niches, or as a result of tissue damage [15]. Remarkably, experimental diabetic cardiomyopathy has been related to a reduction in CD117 + cardiac-resident progenitor cells [16], which can be detected in the bloodstream in certain conditions [17]. The study by Egan et al moves away from strictly considering progenitors for the endothelial lineage towards a more general evaluation of multi-lineage progenitor cells that may have important functions in the cardiovascular system of diabetic patients.…”

Bone Marrow Derived Pluripotent Stem Cells in Ischemic Heart Disease: Bridging the Gap Between Basic Research and Clinical Applications

“…BM-derived pluripotent stem cells are mobilized in the peripheral circulation following myocardial ischemia in animal models and humans Myocardial ischemia, particularly large myocardial infarction, produce multiple stimuli include various chemokines, cytokines, kinins, bioactive lipids and members of the complement cascade, that lead to the mobilization and subsequent homing of BMSPCs. Indeed, several reports have confirmed that mobilization of stem cells originating from the BM occurs in response to myocardial ischemic injury (Grundmann et al, 2007;Kucia et al, 2004b;Leone et al, 2005;Massa et al, 2005;Shintani et al, 2001;Wojakowski et al, 2006) and heart failure (Valgimigli et al, 2004). Similar observations were noted in patients with acute neurological ischemia (Paczkowska et al, 2005) and patients with extensive skin burn (Drukala et al, 2011).…”

“…Similarly, Wojakowski et al demonstrated the mobilization of multiple BM-SPCs populations in patients with AMI and found significant correlation between the number of circulating CD34+ cells and plasma SDF-1 levels (Wojakowski et al, 2004). In their following publication, the authors demonstrated the correlation between circulating BM-SPCs and ejection fraction at baseline and lower brain natriuretic peptide (BNP) levels (Wojakowski et al 2006). Interestingly, the mobilization of BM-SPCs is reduced by the successful revascularization of the culprit vessel in acute STEMI (Müller-Ehmsen et al, 2005).…”

“…Indeed, there is evidence that the mobilization of CXCR4+ cells in the setting of AMI is correlated with LVEF recovery as well as myocardial reperfusion when assessed with cardiac MRI in humans (Wojakowski, et al 2006). …”