Mobilization and collection of peripheral blood stem cells in healthy donors: Risks, adverse events and follow-up

Moalic, V.

doi:10.1016/j.patbio.2012.10.003

Cited by 7 publications

(8 citation statements)

References 43 publications

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“…Splenic rupture, allergic reaction and two cases of arterial thrombosis have been reported in literature as rare complications in healthy donors. Plerixafor can induce transient side effects as gastro intestinal discomfort, diarrhea, nausea, erythema in injection site, headache and paraesthesia [13,37]. …”

Section: Discussionmentioning

confidence: 99%

Mobilization, Isolation and Characterization of Stem Cells from Peripheral Blood: a Systematic Review

Yosupov¹,

Haimov²,

Juodžbalys³

2017

JOMR

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ObjectivesThe purpose of this article is to systematically review the methods of mobilization, isolation and characterization of stem cells from peripheral blood and to discuss their potential therapeutic applications for bone tissue regeneration.Material and MethodsAn electronic literature search was performed through MEDLINE (PubMed) electronic database. The search was restricted to English language articles published during the last 10 years, from January 2006 to November 2016.ResultsIn total, 37 literature sources were reviewed, and 11 of the most relevant articles that are suitable to the criteria were selected. Articles were analysed with data on animals and humans for mobilization, isolation and characterization of stem cells from peripheral blood. From the examination of selected articles, the mobilization materials, side effects, alternatives and factors affecting the extracted amount of mesenchymal stem cells (MSC) from mobilized peripheral blood of healthy individuals, as well as characterization of mobilized MSC were reviewed in this article.ConclusionsBone tissue engineering is a potential alternative strategy in bone regeneration and bone defect repair, however, insufficiency data display in the literature on potential therapeutic applications of peripheral blood stem cells for bone tissue regeneration.

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Section: Discussionmentioning

confidence: 99%

Mobilization, Isolation and Characterization of Stem Cells from Peripheral Blood: a Systematic Review

Yosupov¹,

Haimov²,

Juodžbalys³

2017

JOMR

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“…Since G-CSF stimulates stem cells, there have been discussions whether the treatment of donors with G-CSF could lead to cancer of blood-forming cells. 18–20 However, registry studies do not support these theories. 21,22…”

Section: Introductionmentioning

confidence: 99%

The ethical dilemma of granulocyte transfusions

2020

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Granulocyte transfusions have been administered to patients with life-threatening infections for more than five decades. However, to what extent this should be the case is far from established. On the one hand, the clinical effects of these transfusions are difficult to prove in clinical studies, and the donors of granulocytes may be exposed to certain risks. On the other hand, clinical experience seems to support the idea that granulocyte transfusions do play an important role for severely ill patients, and the donors are primarily motivated by altruistic reasons. In this paper, we first discuss the ethical issues that arise from the fact that there is a conflict between clinical experience and the results from the attempts to perform randomized control trials, and second, the risk/benefit assessment that has to be made between two different parties, namely the recipient and the donor of granulocyte transfusions.

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“…Immediate events related to G‐CSF such as fatigue and pain are well known, and usually mild and reversible . Serious adverse events (SAE) such as cardiovascular/thromboembolic events, splenic rupture, and pulmonary symptoms are reported in stem cell donors, where the G‐CSF is dosed differently (by weight) and given in a series . G‐CSF given to stem cell donors has also been discussed as having a potential impact on the developing of hematological malignancies .…”

Section: Introductionmentioning

confidence: 99%

“…Serious adverse events (SAE) such as cardiovascular/thromboembolic events, splenic rupture, and pulmonary symptoms are reported in stem cell donors, where the G‐CSF is dosed differently (by weight) and given in a series . G‐CSF given to stem cell donors has also been discussed as having a potential impact on the developing of hematological malignancies . Data from registries in Europe and in USA does not support this issue , although Hölig et al reported an increased incidence in Hodgkin lymphoma in donors as compared to the natural incidence in the German population .…”

Section: Introductionmentioning

confidence: 99%