Mobility of protein through a porous membrane

Ennis, Jonathan; Zhang, H.; Stevens, Geoffrey W.; Perera, Jilska M.; Scales, Peter J.; Carnie, Steven L.

doi:10.1016/0376-7388(96)00112-3

Cited by 54 publications

(49 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both these factors are functions of the ratio of the solute radius to pore radius, [20], [21], [14], [30], [38]. The model treats the pores as perfectly cylindrical and the solutes as perfect hard spheres [39] [40] [41]. …”

Section: Historical Development Of the Dspm-de Modelmentioning

confidence: 99%

Effect of temperature on ion transport in nanofiltration membranes: Diffusion, convection and electromigration

2017

View full text Add to dashboard Cite

Nanofiltration performance as a function of feed temperature is relevant to several industrial settings including pretreatment for scale control in thermal desalination. Understanding of solute transport as a function of temperature is critical for effective membrane and system design. In this study, nanofiltration is modeled at 22, 40 and 50 o C using the Donnan Steric Pore Model with dielectric exclusion (DSPM-DE).This modeling includes the temperature dependence of the three modes of solute transport, namely the convective, electromigrative, and diffusive modes, and the three mechanisms of solute exclusion, namely Donnan, steric, and dielectric exclusion. The effect of temperature is captured through the variation of membrane parameters and solvent and ionic mobilities with temperature. We compare the most abundant ionic compound in natural water, sodium-chloride with magnesium-chloride to portray how the salt passage and rejection change for a 1:1 salt compared to a 2:1 salt, and we analyze Arabian Gulf seawater to understand how rejection of scale-forming ions, such as Mg 2+ and Ca 2+ , is affected by feed temperature.In all cases, solute transport increases with temperature, attributed predominantly to the cumulative effect of membrane parameters and only to a small extent (up to 5%) to the solvent viscosity and ion diffusivity together.Keywords: Nanofiltration, Temperature, Ion transport, Desalination

show abstract

Section: Historical Development Of the Dspm-de Modelmentioning

confidence: 99%

Effect of temperature on ion transport in nanofiltration membranes: Diffusion, convection and electromigration

2017

View full text Add to dashboard Cite

show abstract

“…13 Numerical simulations were carried out by Higdon and Muldowney 16 who also fit their results to provide an analytical expression for G(X). Dechadilok and Deen 17 used this expression to determine radially averaged hindrance factors as a function of relative particle size which were in excellent agreement with the expression developed by Ennis et al 15 Anderson 11 theoretically examined the transport of capsule shaped particles in a cylindrical pore by considering only configurational effects (i.e., G(X, w) 5 1 was assumed for all particle positions and orientations). The rejection coefficient for a capsule-shaped particle was predicted to be larger (higher removals) than for a spherical particle with equivalent volume, with rejection coefficient increasing as particle aspect ratio increases.…”

Section: Introductionmentioning

confidence: 58%

“…Ennis et al 15 used a Pad e approximation to combine the small particle expression developed by Brenner and Gaydos 14 with a large particle expression developed by Bungay and Brenner. 13 Numerical simulations were carried out by Higdon and Muldowney 16 who also fit their results to provide an analytical expression for G(X).…”

Section: Introductionmentioning

confidence: 99%

Membrane rejection of nonspherical particles: Modeling and experiment

et al. 2013

View full text Add to dashboard Cite

The rejection coefficient of nonspherical particles from ultrafiltration and microfiltration membranes has been examined from both theoretical and experimental perspectives. Modeling efforts focused on incorporating the convective hindrance factor for a capsule shaped particle in a cylindrical pore into predictions of the rejection coefficient. First, the convective hindrance factor was approximated using previously reported results for the hydrodynamic resistances experienced by a sphere in a pore. Second, computational fluid dynamics calculations predicted the convective hindrance factor for a capsule in a cylindrical pore. Results from both approaches indicate that including hydrodynamic interactions in predictions of the rejection coefficient has a greater effect for smaller particles and particles with smaller aspect ratio (i.e., close to spherical shape). Rejections of several rod-shaped Gram negative bacteria with aspect ratio from 2 to 5 by clean track-etched membranes were in general agreement with theoretical predictions.

show abstract

“…Among these vast studies, Ennis, Keh and Anderson have contributed massive fundamental works on mathematic modeling, provided various clues for further understanding of the membrane-based electrophoresis. Particularly the assumptions described in Ennis et al work [39] are most closed to the reality of our membrane-based electrophoresis. By assuming a thick double layer, an analytical expression of translation velocity (u) of a charged particle through a charged cylindrical pore was proposed by Ennis et al [39].…”

Section: Boundary Effects Of the Membranementioning

confidence: 99%

“…Particularly the assumptions described in Ennis et al work [39] are most closed to the reality of our membrane-based electrophoresis. By assuming a thick double layer, an analytical expression of translation velocity (u) of a charged particle through a charged cylindrical pore was proposed by Ennis et al [39]. Their studies clearly demonstrated that the mass transfer through a membrane-based electrophoresis is determined by the surface z-potentials (of both particles and membrane pores), pore sizes, particle size, buffer concentration and undisturbed applied electric field E N , as shown in Eq.…”

Section: Boundary Effects Of the Membranementioning

confidence: 99%

Investigation of mass transfer in the ion‐exchange‐membrane‐partitioned free‐flow IEF system for protein separation

2009

View full text Add to dashboard Cite

In this study, novel polysulfone-based cation-exchange membranes with strong mechanical strength have been developed and applied in ion-exchange-membrane-partitioned free-flow IEF (IEM-FFIEF) to replace the conventional immobiline membranes. A fundamental understanding of protein mass transfer in the IEM-FFIEF process has been revealed experimentally with the aid of membrane-based boundary effect model contributed by Ennis et al. we have proven experimentally the existence of a pH gradient across the membrane cross-section when an IEM-FFIEF system is in operation. The boundary effects on particle velocities are calculated based on the IEF assumption and various characterizations, and are compared with the experimental results. In the IEM-FFIEF experiments, a protein mixture (BSA and myoglobin (Mb)) and sulfonated polysulfone membranes with different ion-exchange capacities are applied. Experimental results show that the real velocity and real mobility (of Mb in this study) are comparable with the mathematic model developed by Ennis et al. This suggests that the equation proposed by Ennis et al., is sufficient to capture the mass transfer through membrane in the IEM-FFIEF system after considering the effects of pore size distribution and effects of disturbed electric field. The charge properties of the membrane surface play a dominant role on the separation performance of the membranes. The newly developed porous solid-phase ion-exchange membranes may potentially and effectively replace immobilines to perform the selective function for protein separation.

show abstract

Mobility of protein through a porous membrane

Cited by 54 publications

References 16 publications

Effect of temperature on ion transport in nanofiltration membranes: Diffusion, convection and electromigration

Effect of temperature on ion transport in nanofiltration membranes: Diffusion, convection and electromigration

Membrane rejection of nonspherical particles: Modeling and experiment

Investigation of mass transfer in the ion‐exchange‐membrane‐partitioned free‐flow IEF system for protein separation

Contact Info

Product

Resources

About