Mobility of membrane-trapped particles

Stone, Howard A.; Masoud, Hassan

doi:10.1017/jfm.2015.486

Cited by 35 publications

(34 citation statements)

References 41 publications

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“…This approach avoids solution of the flow field u s at the expense of the surface integral over the interface. This derivation is similar to that shown for an inviscid interface (Masoud & Stone 2014) and incompressible interface (Stone & Masoud 2015).…”

Section: Discussionsupporting

confidence: 82%

Surface viscosity and Marangoni stresses at surfactant laden interfaces

2016

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We calculate here the force on a probe at a viscous, compressible interface, laden with soluble surfactant that equilibrates on a finite time scale. The motion of the probe through the interface drives variations in the surfactant concentration at the interface that in turn leads to a Marangoni flow that contributes to the force on the probe. We demonstrate that the Marangoni force on the probe depends non-trivially on the surface shear and dilatational viscosities of the interface indicating the difficulty in extracting these material properties from force measurements at compressible interfaces.

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Section: Discussionsupporting

confidence: 82%

Surface viscosity and Marangoni stresses at surfactant laden interfaces

2016

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“…The ideas used to derive (3.8) are also useful in analysing the motion of a particle at a surfactant-covered interface (Stone & Masoud 2015). The velocity field u (0) for flow about a circular disk translating edgewise is known analytically (e.g.…”

Section: 2mentioning

confidence: 99%

Drag and diffusion coefficients of a spherical particle attached to a fluid–fluid interface

et al. 2016

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Explicit analytical expressions for the drag and diffusion coefficients of a spherical particle attached to the flat interface between two immiscible fluids are constructed for the case of a vanishing viscosity ratio between the fluid phases. The model is designed to account explicitly for the dependence on the contact angle between the two fluids and the solid surface. The Lorentz reciprocal theorem is applied in the context of geometric perturbations from the limiting cases of 90 • and 180 • contact angles. The model agrees well with the experimental and numerical data from the literature. Also, an advantage of the method utilized is that the drag and diffusion coefficients can be calculated up to one order higher in the perturbation parameter than the known velocity and pressure fields. Extensions to other particle shapes with known velocity and pressure fields are straightforward.

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“…Despite needing to be experimentally validated, this is the first graphene–cell membrane interaction state predicted by simulations ( 28 , 29 ). The GO encapsulation makes this superstructure absolutely distinct from the basic features of interfacial transport of membrane-trapped 3D nanoparticles ( 15 , 29 , 30 ) and may allow diverse approaches for novel biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Transport of a graphene nanosheet sandwiched inside cell membranes

et al. 2019

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The transport of nanoparticles at bio-nano interfaces is essential for many cellular responses and biomedical applications. How two-dimensional nanomaterials, such as graphene and transition-metal dichalcogenides, diffuse along the cell membrane is, however, unknown, posing an urgent and important issue to promote their applications in the biomedical area. Here, we show that the transport of graphene oxides (GOs) sandwiched inside cell membranes varies from Brownian to Lévy and even directional dynamics. Specifically, experiments evidence sandwiched graphene–cell membrane superstructures in different cells. Combined simulations and analysis identify a sandwiched GO–induced pore in cell membrane leaflets, spanning unstable, metastable, and stable states. An analytical model that rationalizes the regimes of these membrane-pore states fits simulations quantitatively, resulting in a mechanistic interpretation of the emergence of Lévy and directional dynamics. We finally demonstrate the applicability of sandwiched GOs in enhanced efficiency of membrane-specific drug delivery. Our findings inform approaches to programming intramembrane transport of two-dimensional nanomaterials toward advantageous biomedical applications.

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Mobility of membrane-trapped particles

Cited by 35 publications

References 41 publications

Surface viscosity and Marangoni stresses at surfactant laden interfaces

Surface viscosity and Marangoni stresses at surfactant laden interfaces

Drag and diffusion coefficients of a spherical particle attached to a fluid–fluid interface

Transport of a graphene nanosheet sandwiched inside cell membranes

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