Mobility Decline in Old Age

Rantakokko, Merja; Mänty, Minna; Rantanen, Taina

doi:10.1097/jes.0b013e3182556f1e

Cited by 188 publications

(132 citation statements)

References 32 publications

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“…With increasing age, genetic vulnerabilities, underlying diseases, and physiological impairments increase the risk for decline in physical functioning [50]. Despite it is known that physical activity (PA) prevents functional decline among older people, with a positive influence on health and survival compared with a sedentary lifestyle, inactivity continues to be a major public health problem [70,14,5].…”

Section: Introductionmentioning

confidence: 99%

“…Despite it is known that physical activity (PA) prevents functional decline among older people, with a positive influence on health and survival compared with a sedentary lifestyle, inactivity continues to be a major public health problem [70,14,5]. Actually, a sedentary lifestyle has been linked to a worsening of cellular ageing biomarker such as telomere length (TL) in white-blood-cell [14], with increase of the propensity to aging-related diseases and premature death [50]. Telomeres are repetitive sequences of DNA (5'-TTAGGG n -3') located at the ends of mammalian chromosomes.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Resistance Training and Redox Homeostasis: Correlation with Age-Associated Genomic Changes

Dimauro

Scalabri

Fantini

et al. 2016

Free Radical Biology and Medicine

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a b s t r a c tRegular physical activity is effective as prevention and treatment for different chronic conditions related to the ageing processes. In fact, a sedentary lifestyle has been linked to a worsening of cellular ageing biomarkers such as telomere length (TL) and/or specific epigenetic changes (e.g. DNA methylation), with increase of the propensity to aging-related diseases and premature death.Extending our previous findings, we aimed to test the hypothesis that 12 weeks of low frequency, moderate intensity, explosive-type resistance training (EMRT) may attenuate age-associated genomic changes. To this aim, TL, global DNA methylation, TRF2, Ku80, SIRT1, SIRT2 and global protein acetylation, as well as other proteins involved in apoptotic pathway (Bcl-2, Bax and Caspase-3), antioxidant response (TrxR1 and MnSOD) and oxidative damage (myeloperoxidase) were evaluated before and after EMRT in whole blood or peripheral mononuclear cells (PBMCs) of elderly subjects.Our findings confirm the potential of EMRT to induce an adaptive change in the antioxidant protein systems at systemic level and suggest a putative role of resistance training in the reduction of global DNA methylation. Moreover, we observed that EMRT counteracts the telomeres' shortening in a manner that proved to be directly correlated with the amelioration of redox homeostasis and efficacy of training regime, evaluated as improvement of both muscle's power/strength and functional parameters.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Resistance Training and Redox Homeostasis: Correlation with Age-Associated Genomic Changes

Dimauro

Scalabri

Fantini

et al. 2016

Free Radical Biology and Medicine

View full text Add to dashboard Cite

show abstract

“…In the International Classification of Functioning, Disability and Health (ICF), components of mobility include walking and moving; changing and maintaining body position; carrying, moving, and handling objects; and moving around using transportation (World Health Organisation 2001). Mobility declines with increasing age, and both intrapersonal and environmental risk factors for incident mobility limitations have been identified, including chronic diseases, physical inactivity, poor muscle strength, sensory impairments, and indoor and outdoor environment (Brown and Flood 2013;Rantakokko et al 2013;Yeom et al 2008). Also, psychosocial symptoms, such as depression earlier in life (Hybels et al 2009) and lower social participation (Avlund et al 2004), are linked to old age mobility limitations.…”

Section: Introductionmentioning

confidence: 99%

Work-related stress in midlife is associated with higher number of mobility limitation in older age—results from the FLAME study

Kulmala

Hinrichs

Törmäkangas

et al. 2014

AGE

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The aim of this study is to investigate whether work-related stress symptoms in midlife are associated with a number of mobility limitations during three decades from midlife to late life. Data for the study come from the Finnish Longitudinal Study of Municipal Employees (FLAME). The study includes a total of 5429 public sector employees aged 44-58 years at baseline who had information available on work-related stress symptoms in 1981 and 1985 and mobility limitation score during the subsequent 28-year follow-up. Four midlife work-related stress profiles were identified: negative reactions to work and depressiveness, perceived decrease in cognition, sleep disturbances, and somatic symptoms. People with a high number of stress symptoms in 1981 and 1985 were categorized as having constant stress. The number of self-reported mobility limitations was computed based on an eight-item list of mobility tasks presented to the participants in 1992, 1997, and 2009. Data were analyzed using joint Poisson regression models. The study showed that depending on the stress profile, persons suffering from constant stress in midlife had a higher risk of 30-70 % for having one more mobility limitation during the following 28 years compared to persons without stress after adjusting for mortality, several lifestyle factors, and chronic conditions. A less pronounced risk increase (20-40 %) was observed for persons with occasional symptoms. The study suggests that effective interventions aiming to reduce work-related stress should focus on both primary and secondary prevention. AGE (2014) 36:9722

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“…Significance was set at p < 0.05 depend on the balance, 13 muscle strength 14 and functional mobility. 15 Certainly, these factors determine the threshold of disability (e.g., inability to shop for groceries) and the zone of physical dependence (e.g., inability to get in and out of bed) with special significance for institutionalized elderly people. 16 Therefore, the purpose of this study was to evaluate the relationship between grip strength and physical function in nursing home residents.…”

Section: Discussionmentioning

confidence: 99%

Grip strength predicts physical function in nursing home residents

Raso¹,

Tolea²,

Mancini³

et al. 2017

Medical Express

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PURPOSE:To analyze the relationship of grip strength and physical function in institutionalized older people. METHODS: One hundred and fifty-seven nursing home residents of seven different long-stay institutions underwent evaluation of body composition, cognitive function, grip strength, mobility, balance (balance scale test BERG and single-leg stance test) and gait speed. RESULTS: Volunteers had no impairment of cognitive function, functional mobility, balance or gait speed. Men had higher grip strength and achieved higher scores in BERG. Fittest volunteers (i.e., P 75 to P 100 ) had better functional mobility, BERG and gait speed; less fit volunteers (i.e., P 0 to P 25 ) were taller and had better gait speed. The grip strength was independently associated with functional mobility and balance in the single-leg stance test only in females. The cognitive function (female, P 25 to P 75 , male, total sample) and age (male, total sample) showed a tendency to be mediators of functional mobility. Age and body weight seem to confound the gait speed, especially for females (P 25 to P 75 ), while cognitive function confound it in males (P 75 to P 100 ). However, age and body weight are significantly associated with gait speed (female, total sample). CONCLUSION: We can conclude that grip strength was independently associated with functional mobility and balance of institutionalized older women.

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Mobility Decline in Old Age

Cited by 188 publications

References 32 publications

Resistance Training and Redox Homeostasis: Correlation with Age-Associated Genomic Changes

Resistance Training and Redox Homeostasis: Correlation with Age-Associated Genomic Changes

Work-related stress in midlife is associated with higher number of mobility limitation in older age—results from the FLAME study

Grip strength predicts physical function in nursing home residents

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