Mobilities of metal β‐diketonato complexes in micellar electrokinetic chromatography

Saitoh, Koichi; Kiyohara, Chikara; Suzuki, N.

doi:10.1002/jhrc.1240140408

Cited by 46 publications

(13 citation statements)

References 10 publications

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“…From the recorded trace of the conductivity 5 I S change with time, the conductivity and the molar equivalent conductivity were plotted against the SDS concentration. The CMC was obtained from the inflection point of the plots, as described by Saitoh et al [6].…”

Section: Methodsmentioning

confidence: 99%

Measurement of thermodynamic quantities of micellar solubilization by micellar electrokinetic chromatography with sodium dodecyl sulfate

Terabe

Katsura

Okada

et al. 1993

J Microcolumn Separations

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Abstract. Micellar electrokinetic chromatography (MEKC) allows the calculation of distribution coefficients between a micelle and the surrounding aqueous phase from the measurement of the migration time, provided the critical micelle concentration (CMC) and the phase ratio are known. Thermodynamic quantities such as enthalpy and entropy changes of micellar solubilization were calculated from the temperature dependence of the distribution coefficients. Sodium dodecyl sulfate (SDS) was employed to prepare a micellar solution and its CMCs and partial specific volumes at different temperatures were measured. The relationship between the molecular structures of solutes and the resulting thermodynamic quantities was investigated. The temperature inside the capillary was calculated from the temperature dependence of the distribution coefficient.

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Section: Methodsmentioning

confidence: 99%

Measurement of thermodynamic quantities of micellar solubilization by micellar electrokinetic chromatography with sodium dodecyl sulfate

Terabe

Katsura

Okada

et al. 1993

J Microcolumn Separations

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“…All other retention models, operating with Eq. (4), known to us [31,36,37], encompass close structural analogs variable by only the nature of ligand substituents. Table 4 demonstrates the performance of correlation analysis explored using a range of MEEKC systems.…”

Section: Correlation Analysismentioning

confidence: 99%

Application of micellar and microemulsion electrokinetic chromatography for characterization of gallium(III) complexes of pharmaceutical significance

Timerbaev

Vasylenko

Foteeva

et al. 2007

J of Separation Science

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CE with conventional UV detection has recently been shown as a highly effective means to assaying cytotoxic gallium(III)-based compounds with regard to desirable drug-like properties such as the stability and binding to serum proteins. In this extension of that work, different CE techniques are used to further characterize a given set of gallium coordination compounds with established antiproliferating efficacy. Using free-zone CE mode, the electrophoretic profiles of complexes are recorded in order to assess their actual charge state under physiological buffer conditions. Micellar and microemulsion electrokinetic chromatographic techniques are tested as tools for the rapid estimation of the n-octanol-water partition coefficient (log P) that provides a rationale estimate of a drug's ability to cross biological membranes. A range of electrolyte buffer systems with varying (both in the nature and concentration) organic modifiers are examined to evaluate their effect on the relationship between experimental or calculated log P and the retention factors of compounds (log k'). Both methods were found to be better applicable for neutral than for cationic Ga complexes, the microemulsion mode demonstrating superior lipophilicity estimations as well as statistically meaningful log P versus log k' correlations when all the complexes were included in one regression set.

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“…Thus, electrically neutral β-diketonates Cr(dik) 3 , Co(dik) 3 , Rd(dik) 3 , Pt(dik) 2 and Pd(dik) 2 were separated by CZE in micellar solutions of sds. A linear log-log relationship was found between the distribution coefficient and the partition coefficient of the complex between dodecane and water, which was used for prediction of both the distribution coefficients and the migration times of different metal complexes 104 .…”

Section: Electrophoresismentioning

confidence: 99%

Analytical Aspects of Metal Enolates

Harlev

Bittner

Zabicky

2010

Patai's Chemistry of Functional Groups

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Mobilities of metal β‐diketonato complexes in micellar electrokinetic chromatography

Cited by 46 publications

References 10 publications

Measurement of thermodynamic quantities of micellar solubilization by micellar electrokinetic chromatography with sodium dodecyl sulfate

Measurement of thermodynamic quantities of micellar solubilization by micellar electrokinetic chromatography with sodium dodecyl sulfate

Application of micellar and microemulsion electrokinetic chromatography for characterization of gallium(III) complexes of pharmaceutical significance

Analytical Aspects of Metal Enolates

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