Mobilisation of mesenchymal cells in cardiac patients: is intense exercise necessary?: Figure 1

Abstract

Circulating mesenchymal cells (cMCs) have a potential for regenerating damaged tissue, e.g., ischaemic myocardium. In patients (age range: 53-76 years) with stable coronary artery disease cMCs were determined before and after dynamic exercise of moderate (< respiratory compensation threshold (RCT)) (n = 9 patients) or high intensity (>RCT) (n = 11). Only high-intensity exercise (i.e., provoking signs of myocardial ischaemia in 3 patients and ventricular extrasystoles in another) induced a significant increase in cMCs (p = 0.009). These results support the hypothesis that intense exercise (near or at the point of myocardial ischaemia) is a potent stimulus for MC mobilisation.

Exercise is the Real Polypill

“…Regardless of their origin (mainly, but not only, bone marrow and adipose tissue), they represent pluripotent progenitors of mesoderm-or even non-mesoderm-derived tissues with a wide variety of therapeutic potential (graft vs. host or Crohn's disease, wound healing or as vehicles of anticancer genes) (139,536). Intense exercise, whether inducing (395) or not inducing eccentric muscle damage, is a potent stimulus for MSC release to the bloodstream (280,432). Vigorous exertion also increases the migratory capacity of MSCs, an effect potentially mediated by the myokine IL-6 (432).…”

“…Vigorous exertion also increases the migratory capacity of MSCs, an effect potentially mediated by the myokine IL-6 (432). Similar to what occurs with CAC, intense exercise-inducing transient ischemia can increase circulating MSCs in CVD patients (280), which is a potentially promising finding because, together with the few cardiac-resident SCs, MSCs have the potential to repair damaged myocardium (518). However, actual engraftment of migratory MSCs in damaged tissue (muscle, myocardium) remains to be demonstrated.…”

Crucial Role of IL1beta and C3a in the In Vitro-Response of Multipotent Mesenchymal Stromal Cells to Inflammatory Mediators of Polytrauma

“…In recent years, it became apparent that the numbers of multipotent mesenchymal stromal cells (MSC) in the blood significantly increases after injury such as hip or lower extremities fractures, acute myocardial infarction, muscle damage and severe tissue hypoxia [ 14 – 17 ]. Since the immunophenotype and differentiation potential of these MSC were shown to be similar to those of MSC isolated from the bone marrow [ 15 ], one explanation could be that MSC are systemically recruited from the bone marrow to various tissues.…”

Another major win for physiotherapy — curing patellofemoral pain

“…Prevention is based on understanding mechanisms and this month we learn about knee joint laxity and its changes during phases of the menstrual cycle from the renowned McCaig Centre at the University of Calgary ( see ) 9 . And in keeping with Obama’s potentiating stem cell research in the US, ( see and )10 11 we examine exercise influences on multipotential stem cells (the MSCs above). Physical activity influences everything!…”