Mobile Video

Bader, Joachim

doi:10.1007/978-3-322-88989-8_13

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Part of the beneficial effects of forced perfusion setups may in fact result from mixing of the culture medium around the construct due to fluid flow in the container, rather than from the forced perfusion itself. This mixing effect has been shown very important [33,37] and many bioreactor systems have therefore included a method for mixing the culture medium ('MIX' in Table 1) [41,43,60,62,63,[66][67][68]79]. This way the tissue is kept in place and additional mechanical stimulation by compression plates is enables.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Review on Patents for Mechanical Stimulation of Articular Cartilage Tissue Engineering

Donkelaar¹,

Schulz

2008

BIOMENG

View full text Add to dashboard Cite

Abstract:To repair articular cartilage defects in osteoarthritic patients with three-dimensional tissue engineered chondrocyte grafts, requires the formation of new cartilage with sufficient mechanical properties. The premise is that mechanical stimulation during the culturing process is necessary to reach this aim. Therefore, mechanical stimulation systems have been integrated in aseptic bioreactors for in vitro cultivation of tissue engineered cartilage. These vary from simple unconfined compression systems to advanced bioreactors in which deformation and loading are fully controlled. Fluid handling in these devices is another decisive parameter for the success of cartilage tissue engineering.Over the last decades bioreactor developments have resulted in the filing of many patents. The aim of this paper is to review these patents, categorize them according to their possibilities for mechanical stimulation and fluid handling systems and finally to discuss them in the context of the demands of a functional tissue engineered cartilage from a mechanical perspective.

show abstract

Section: Discussionmentioning

confidence: 99%

“…One reason for designing the bioreactor this way can be to ensure limited resistance. Other designs seem to allow both unconfined and confined compression, because the piston diameter matches the diameter of the container [41,42,[65][66][67]. If in these cases the sample fits the container, loading is confined.…”

Section: Confined and Unconfined Compressionmentioning

confidence: 99%

Review on Patents for Mechanical Stimulation of Articular Cartilage Tissue Engineering

Donkelaar¹,

Schulz

2008

BIOMENG

View full text Add to dashboard Cite

show abstract

Mobile Video

Cited by 1 publication

References 0 publications

Review on Patents for Mechanical Stimulation of Articular Cartilage Tissue Engineering

Review on Patents for Mechanical Stimulation of Articular Cartilage Tissue Engineering

Contact Info

Product

Resources

About