Mobile phone (MP) has become inseparable part of human life, both personal, and professional including health-care related ones. MP usage has increased from 10 to 60%in just 8-year period from 2011 to 2018, and is predicted to be around 80% by 2025 [1]. There are around 5.07 billion MPs users worldwide, of which India inhabits 23%, that is, almost 1.2 billion users which is only next to China [2,3].In health-care setting, apart from communication, MPs can be very handy in exploring information at point of care, which ultimately provides best possible evidence based practices to patients, along with using different medical applications for dayto-day practice; although, they also act as a source of distraction and compromise aseptic environment [4]. With present ongoing pandemic there is lot of stress on teleconsultations leading to widespread usage of smartphones in intensive care unit (ICU).MPs are frequently used and come in contact of face and hands, they heat up to a considerable temperature when used, thereby promoting for bacterial growth and its transmission. However, as there were no guidelines for its cleaning or disinfection and not being a common practice, as per a report almost 72% users have never cleaned their device. Thus MPs are often full of microbial contamination acting as fomites and are potential risk factor for disease transmission through fomites in public health globally [5].MPs are touched on an average 3 h/day and are contaminated by plethora of organisms [6]. In an Indian study, almost 100% healthcare workers (HCW) used MPs in health-care setting but only 10% had ever cleaned them [7]. The overall impact of potential harm of MP contamination can only be ascertained on the basis of magnitude of the mobile usage for various practices, personal beliefs, and knowledge of HCW about cleaning and disinfection practices. Therefore, the study was aimed to assess the knowledge, attitude, and practices of MP usage and disinfection among health-care providers in a tertiary care hospital. This would help in identifying the sectors in which efforts should be done for the improvement.