Mobile phone induced EMF stress is reversed upon the use of protective devices: results from two experiments testing different boundary conditions

Schneider, Rainer

doi:10.1080/15368378.2022.2129380

Cited by 3 publications

(1 citation statement)

References 32 publications

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“…Electromagnetic radiation has emerged as an important new source of pollution in modern civilization and has been classified as a possible human carcinogen by the International Agency for Research on Cancer [ 24 , 25 ], and its effects on the heart have also been demonstrated [ 26 , 27 ]. Because different microwave radiation source devices were not completely consistent, there was a lack of reproducibility in radiation conditions and methods of modeling.…”

Section: Discussionmentioning

confidence: 99%

Role of Cx43 in iPSC-CM Damage Induced by Microwave Radiation

Yin,

Xu,

et al. 2023

IJMS

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The heart is one of the major organs affected by microwave radiation, and these effects have been extensively studied. Previous studies have shown that microwave-radiation-induced heart injury might be related to the abnormal expression and distribution of Cx43. In order to make the research model closer to humans, we used iPSC-CMs as the cell injury model to investigate the biological effect and mechanism of iPSC-CM injury after microwave radiation. To model the damage, iPSC-CMs were separated into four groups and exposed to single or composite S-band (2.856 GHz) and X-band (9.375 GHz) microwave radiation sources with an average power density of 30 mW/cm2. After that, FCM was used to detect cell activity, and ELISA was used to detect the contents of myocardial enzymes and injury markers in the culture medium, and it was discovered that cell activity decreased and the contents increased after radiation. TEM and SEM showed that the ultrastructure of the cell membrane, mitochondria, and ID was damaged. Mitochondrial function was aberrant, and glycolytic capacity decreased after exposure. The electrical conduction function of iPSC-CM was abnormal; the conduction velocity was decreased, and the pulsation amplitude was reduced. Wb, qRT-PCR, and IF detections showed that the expression of Cx43 was decreased and the distribution of Cx43 at the gap junction was disordered. Single or composite exposure to S- and X-band microwave radiation caused damage to the structure and function of iPSC-CMs, primarily affecting the cell membrane, mitochondria, and ID. The composite exposure group was more severely harmed than the single exposure group. These abnormalities in structure and function were related to the decreased expression and disordered distribution of Cx43.

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