Mobile Phone Imaging in Low Resource Settings for Early Detection of Oral Cancer and Concordance with Clinical Oral Examination

Haron, Nabihah; Zain, Rosnah Binti; Nabillah, Wan Maria; Saleh, Amyza; Kallarakkal, Thomas George; Ramanathan, Anand; Sinon, Suraya Hani Mohd.; Razak, Ishak Abdul; Cheong, Sok Ching

doi:10.1089/tmj.2016.0128

Cited by 57 publications

(78 citation statements)

References 22 publications

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“…Recent advances in imaging techniques, including CBCT and digital intra‐oral surface scans of the teeth, have created new means for recording information that intraoral photographs have historically captured. New treatment methods, including teledentistry techniques, rely increasingly on photographs, video‐based interaction, and other records for diagnosis, rather than in‐person examinations …”

Section: Introductionmentioning

confidence: 99%

“…New treatment methods, including teledentistry techniques, rely increasingly on photographs, video-based interaction, and other records for diagnosis, rather than in-person examinations. [9][10][11] In the current practice environment where practical technology exists that might replace intraoral photography, how relevant are photos to orthodontic diagnosis and record-keeping? Importantly, how accurate is the diagnostic process using current standard of care intraoral photographs?…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic accuracy of intraoral photographic orthodontic records

Jackson

Kirk²,

Phillips

et al. 2018

J Esthet Restor Dent

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Objective The aims of this study were (1) to investigate how relevant intraoral photographs are to contemporary orthodontic diagnosis and (2) to assess orthodontists' ability to accurately diagnose angle classification and dental midlines using standardized intraoral photographs. Methods Study participants were orthodontists who completed a survey regarding photography protocols and their use of intraoral photographs for diagnosis. Each participant was randomized to complete 1 visual diagnostic task regarding either angle classification or midlines. Accuracy was compared across groups and camera angulations. Results In all, 80% of 192 respondents reported using photographs and clinic notes to plan orthodontic treatment; 50% also included dental casts. For the angle task, accuracy judging molar and canine classification was 79.9% and 51.3%, respectively with ideal standardized photographs. As camera angulation deviated, accuracy decreased significantly (P < 0.0001). For the midline task, accuracy judging the direction of deviation decreased with a small camera angulation change yet increased with a large change (P < 0.001). Conclusions When using ideal intraoral photographs alone to diagnose angle classification and midline relationships, accuracy is not likely to be greater than 80%. As camera angulation becomes less ideal, by 15 degrees when judging angle classification or 4 degrees when judging midlines, accuracy is likely to significantly decrease. Clinical significance For the clinician who wants to have the most accurate and complete records, our results suggest that intra‐oral photos alone may not be adequate when it comes to judging occlusal relationships such as angle classification and esthetic parameters like midlines. When using ideal intraoral photographs to diagnose angle classification and midline relationships, accuracy is not likely to be greater than 80%. As camera angulation becomes less ideal, by as little as 15 degrees when judging angle classification or 4 degrees when judging midlines, accuracy is likely to decrease significantly. Understanding these limitations will allow clinicians to improve both their clinical photography technique and their diagnostic skills.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diagnostic accuracy of intraoral photographic orthodontic records

Jackson

Kirk²,

Phillips

et al. 2018

J Esthet Restor Dent

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“…A large number of mobile health solutions have been presented within this field, including applications for emergency medicine, surgery, otolaryngology, ophthalmology, dermatology, radiology, pathology and general medicine [4]. Specific applications such as burn injury consultation [5], oral cancer diagnostics [6], diagnosis of middle-ear infections [7], refraction tests and cataract assessment (Eyenetra, Somerville, MA), skin cancer detection (SkinVision, SkinVision BV, Amsterdam, Netherlands and MoleScope, MetaOptima, Vancouver, BC) and parasite and cancer microscopy-based diagnosis [8–10] to name a few. A series of portable ultrasound systems are available that can display the image on portable devices, providing rugged low-cost systems that do not compromise the image quality (VScan, GE Healthcare, Chicago, IL, and Clarius, Burnaby BC, Canada).…”

Section: Introductionmentioning

confidence: 99%

Medical mobile technologies – what is needed for a sustainable and scalable implementation on a global scale?

Lundin

Dumont

2017

Global Health Action

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Current advances within medical technology show great potential from a global health perspective. Inexpensive, effective solutions to common problems within diagnostics, medical procedures and access to medical information are emerging within almost all fields of medicine. The innovations can benefit health care both in resource-limited and in resource-rich settings. However, there is a big gap between the proof-of-concept stage and implementation. This article will give examples of promising solutions, with special focus on mobile image- and sensor-based diagnostics. We also discuss how technology and frugal innovations could be made sustainable and widely available. Finally, a list of critical factors for success is presented, based on both our own experiences and the literature.

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“…Most of these types of cancers are considered squamous cell carcinomas, i.e., mucosal variations (1). Oral cancer generally includes gingival and tongue cancer, and is commonly seen in the head and neck (2). Most types of oral cancer are related to unhealthy living habits, such as the oral use of tobacco and betel leaf.…”

Section: Introductionmentioning

confidence: 99%

Effects and mechanism of GA-13315 on the proliferation and apoptosis of KB cells in oral cancer

Shen

Tang

2017

Oncology Letters

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The present study describes the effects and mechanism of GA-13315 on the proliferation and apoptosis of KB cells in oral cancer. Oral cancer is twice as common in men than women. More than 90% of oral cancers in men and 85% in women are linked to lifestyle and environmental factors. PPP2R2B methylation may be associated with survival and prognosis in patients with gliomas. In tumor cell proliferation and apoptosis, the mechanism of PPP2R2B remains unclear. In the present study, we found that PPP2R2B expression of H1299 cells is significantly decreased after being treated by GA-13315. KB cells were isolated from patients with oral cancer and treated with GA-13315 (5 µM). Cells without GA-13315 treatment served as the control group. An MTT experiment was performed to detect the post-treatment cell growth between the groups. A flow cytometry was used to detect cell apoptosis. Western blot analysis and quantitative polymerase chain reaction methods were used for detecting the expression of PPP2R2B. Compared with the control group, the cell proliferation of the treatment group slowed after being treated with GA-13315. The difference was statistically significant (P<0.05). Western blotting showed that the PPP2R2B expression of cells was reduced after being treated with GA-13315. Compared with the control group, the difference was statistically significant (P<0.05). According to results from the Transwell migration assay, the invasiveness of the KB cells of oral cancer were weakened after being treated by GA-13315. GA-13315 can accelerate the apoptosis of oral cancer cells and presents a dose correlation. The biological effect is exerted through the decrease of PPP2R2B.

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Mobile Phone Imaging in Low Resource Settings for Early Detection of Oral Cancer and Concordance with Clinical Oral Examination

Abstract: This study provides evidence that teledentistry can be used for communication between primary care and OMS and could be readily integrated into clinical setting for patient management.

Cited by 57 publications

References 22 publications

Diagnostic accuracy of intraoral photographic orthodontic records

Diagnostic accuracy of intraoral photographic orthodontic records

Medical mobile technologies – what is needed for a sustainable and scalable implementation on a global scale?

Effects and mechanism of GA-13315 on the proliferation and apoptosis of KB cells in oral cancer

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