Mobile digital gait analysis captures effects of botulinum toxin in hereditary spastic paraplegia
Alzhraa A. Ibrahim,
Malte Ollenschläger,
Stephan Klebe
et al.
Abstract:Background and purposeHereditary spastic paraplegias (HSPs) comprise a group of inherited neurodegenerative disorders characterized by progressive spasticity and weakness. Botulinum toxin has been approved for lower limb spasticity following stroke and cerebral palsy, but its effects in HSPs remain underexplored. We aimed to characterize the effects of botulinum toxin on clinical, gait, and patient‐reported outcomes in HSP patients and explore the potential of mobile digital gait analysis to monitor treatment … Show more
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