Mo1934 - Gut Microbial Markers of Arthritis Including Inflammatory Bowel Disease Associated Arthropathy

Muñiz-Pedrogo, David A.; Hillmann, Benjamin; Jeraldo, Patricio; Saffouri, George; Al‐Ghalith, Gabriel A.; Friton, Jessica J.; Taneja, Veena; Davis, John M.; Knights, Dan; Faubion, William A.; Raffals, Laura H.; Kashyap, Purna C.

doi:10.1016/s0016-5085(18)32898-1

Cited by 4 publications

(5 citation statements)

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Section: Resultsmentioning

confidence: 99%

“…76 Moreover, upon ETN treatment, a decrease in Clostridiaceae was observed, which were previously found enriched in patients with RA and IBD-associated arthropathy. 77 In patients treated with MTX, analysis revealed a significant decrease in Enterobacteriales. 75 Liu et al reported that RA patients, compared with healthy subjects, exhibited an increased bacterial diversity within the Lactobacillus community with increase in L. salivarius and L. iners, 70,78,79 for instance.…”

Section: Bacteroidetesmentioning

confidence: 99%

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Gut microbiome in chronic rheumatic and inflammatory bowel diseases: Similarities and differences

et al. 2019

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Introduction Inflammatory bowel diseases (IBDs) and chronic rheumatic diseases (CRDs) are systemic chronic disorders sharing common genetic, immune and environmental factors. About half of patients with IBD develop rheumatic ailments and microscopic intestinal inflammation is present in up to half of CRD patients. IBD and CRD patients also share a common therapeutic armamentarium. Disequilibrium in the complex realm of microbes (known as dysbiosis) that closely interact with the gut mucosal immune system has been associated with both IBD and CRD (spondyloarthritis and rheumatoid arthritis). Whether dysbiosis represents an epiphenomenon or a prodromal feature remains to be determined. Methods In an attempt to further investigate whether specific gut dysbiosis may be the missing link between IBD and CRD in patients developing both diseases, we performed here a systematic literature review focusing on studies looking at bacterial microbiota in CRD and/or IBD patients. Results We included 80 studies, with a total of 3799 IBD patients without arthritis, 1084 CRD patients without IBD, 132 IBD patients with arthropathy manifestations and 12 spondyloarthritis patients with IBD history. Overall, this systematic review indicates that an increase in Bifidobacterium, Staphylococcus, Enterococcus, Lactobacillus, Pseudomonas, Klebsiella and Proteus genera, as well as a decrease in Faecalibacterium, Roseburia genera and species belonging to Verrucomicrobia and Fusobacteria phyla are common features in IBD and CRD patients, whereas dozens of bacterial species are specific features of CRD and IBD. Conclusion Further work is needed to understand the functions of bacteria and of their metabolites but also to characterize fungi and viruses that are commonly found in these patients.

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Section: Resultsmentioning

confidence: 99%

Section: Bacteroidetesmentioning

confidence: 99%

Gut microbiome in chronic rheumatic and inflammatory bowel diseases: Similarities and differences

et al. 2019

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“…Also, the drop in Deltaproteobacteria caused by ETN could be potentially beneficial if we consider that these microorganisms were found enriched in patients suffering from ulcerative colitis [ 33 ] and that Proteobacteria in general are abundant in both intestinal and extra-intestinal inflammatory diseases [ 34 ]. Moreover, we observed a decrease in Clostridiaceae upon ETN treatment which could be potentially beneficial since these bacteria were previously found enriched in patients with RA and IBD-associated arthropathy [ 35 ]. In patients treated with MTX, our analysis revealed a significant decrease in Enterobacteriales, whose lipopolysaccharides may contribute to inflammation [ 36 ], and which were associated with increased intestinal permeability [ 37 ], a condition that can be found in RA patients [ 38 ].…”

Section: Discussionmentioning

confidence: 96%

Analysis of Gut Microbiota in Rheumatoid Arthritis Patients: Disease-Related Dysbiosis and Modifications Induced by Etanercept

Picchianti-Diamanti

Panebianco

Salemi

et al. 2018

IJMS

163

149

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A certain number of studies were carried out to address the question of how dysbiosis could affect the onset and development of rheumatoid arthritis (RA), but little is known about the reciprocal influence between microbiota composition and immunosuppressive drugs, and how this interaction may have an impact on the clinical outcome. The aim of this study was to characterize the intestinal microbiota in a groups of RA patients treatment-naïve, under methotrexate, and/or etanercept (ETN). Correlations between the gut microbiota composition and validated immunological and clinical parameters of disease activity were also evaluated. In the current study, a 16S analysis was employed to explore the gut microbiota of 42 patients affected by RA and 10 healthy controls. Disease activity score on 28 joints (DAS-28), erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor, anti-cyclic citrullinated peptides, and dietary and smoking habits were assessed. The composition of the gut microbiota in RA patients free of therapy is characterized by several abnormalities compared to healthy controls. Gut dysbiosis in RA patients is associated with different serological and clinical parameters; in particular, the phylum of Euryarchaeota was directly correlated to DAS and emerged as an independent risk factor. Patients under treatment with ETN present a partial restoration of a beneficial microbiota. The results of our study confirm that gut dysbiosis is a hallmark of the disease, and shows, for the first time, that the anti-tumor necrosis factor alpha (TNF-α) ETN is able to modify microbial communities, at least partially restoring a beneficial microbiota.

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“…The arthrogenic role of Collinsella has been confirmed in both cell-based and humanized murine models of arthritis [15], possibly by means of increasing gut mucosal permeability observed in RA [55]. In addition, gut microbiota enriched with Akkermansia and Clostridiales has been found in RA patients or inflammatory bowel disease-associated arthropathy [43,56]. However, the causal relationship between RF/ACPA seropositivity and the composition of gut microbiota needs to be elucidated in the future.…”

Section: Discussionmentioning

confidence: 99%

“…The understanding of the dysbiosis of gut microbiota in human RA has opened up a window to more therapeutic opportunities such as modulating microbes through diet and probiotics [57,58]. Probiotic administration with immunomodulatory microbial species has shown some benefits [56], and intervention targeting gut microbiota in RA patients has also shown the potential to revolutionize the modern therapeutics [59].…”

Section: Discussionmentioning

confidence: 99%

An Association of Gut Microbiota with Different Phenotypes in Chinese Patients with Rheumatoid Arthritis

Chiang

Lǐ

Liu

et al. 2019

JCM

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We aimed to investigate the association of gut microbiota with disease activity, inflammatory parameters, and auto-antibodies profile in rheumatoid arthritis (RA). A total of 138 RA patients and 21 healthy controls (HC) were enrolled. Fecal samples were collected for bacterial DNA extraction and 16S ribosome (r)RNA sequencing, followed by analyses of gut microbiota composition. Serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-17A were determined by using ELISA. Our results indicated that RA patients had lower diversity index, which reflects both evenness and richness of gut microbiota, compared to HC. The alpha-diversity was lower in anti-citrullinated peptide antibodies (ACPA)-positive patients than in HC. The phylum Verrucomicrobiae and genus Akkermansia were more abundant in patients compared to HC. There was increased relative abundance of Enterobacteriaceae as well as Klebsiella, and less abundance of Bifidobacterium in patients with high levels of TNF-α or IL-17A compared to those who had low levels of these cytokines. In addition, ACPA-positive patients had higher proportions of Blautia, Akkermansia, and Clostridiales than ACPA-negative patients. Gut dysbiosis in RA patients was presented as different microbial composition and its association with inflammatory parameters as well as ACPA seropositivity. These findings support the involvement of gut microbiota in RA pathogenesis.

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Mo1934 - Gut Microbial Markers of Arthritis Including Inflammatory Bowel Disease Associated Arthropathy

Cited by 4 publications

References 0 publications

Gut microbiome in chronic rheumatic and inflammatory bowel diseases: Similarities and differences

Gut microbiome in chronic rheumatic and inflammatory bowel diseases: Similarities and differences

Analysis of Gut Microbiota in Rheumatoid Arthritis Patients: Disease-Related Dysbiosis and Modifications Induced by Etanercept

An Association of Gut Microbiota with Different Phenotypes in Chinese Patients with Rheumatoid Arthritis

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