Mo1924 - Probiotics for the Prevention of Clostridium-Difficile Associated Diarrhea in Adults and Children

Goldenberg, Joshua Z.; Yap, Christina; Lytvyn, Lyubov; Lo, Calvin Ka-Fung; Beardsley, Jennifer; Mertz, Dominik; Johnston, Bradley C.

doi:10.1016/s0016-5085(18)32888-9

Cited by 1 publication

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“…Probiotics are live microorganisms that are thought to improve the balance of host microbes, prevent potential disruptions to the intestinal flora associated with antibiotic use, reduce the risk of colonization by pathogenic bacteria in the intestinal wall, increase the production of antimicrobial substances, and change in the acidity of the intestinal environment to minimize the possibility of infection by producing fatty acids [33].…”

Section: Types and Dosages Of Probioticsmentioning

confidence: 99%

Probiotics and Their Role in Decreasing Diarrhea Prevalence in the Elderly Population: A Comprehensive Meta-Analysis

Muliana,

Mulia,

Suardi

et al. 2024

Malacca Pharm.

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Diarrhea is an atypical state of the digestive system characterized by a soft or watery texture in bowel movements. Antibiotic-related diarrhea is common in the elderly due to extensive antibiotic use. Probiotics are vital microorganisms that support the intestinal flora and reduce bacterial colonization in the intestinal wall. This study aimed to assess the effectiveness, type, and dose of probiotics for diarrhea in the elderly. A systematic review with meta-analysis was conducted using PubMed, ScienceDirect, and Google Scholar. Seven records with a total of 2,087 participants were included. A quantitative analysis was carried out using Review Manager version 5 software. A meta-analysis was conducted to assess the frequency of diarrhea. The results showed that using probiotics significantly reduced the risk of antibiotic-related diarrhea 0.53 times compared to the placebo administration (OR 0.53; CI 95% 0.29 to 0.98; I2 = 70%). The type of probiotics frequently given was the genera of Lactobacillus, Bifidobacterium, and Streptococcus, with consumption durations varying from 3 days to a maximum of 4 weeks. The dose of probiotics ranged from a minimum of 1.0 × 10⁶ CFU to a maximum dose of 2 × 10¹⁰ CFU. To conclude, probiotic administration is more effective than placebo in reducing the risk of antibiotic-related diarrhea in the elderly.

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Section: Types and Dosages Of Probioticsmentioning

confidence: 99%