Mo1800 Colonic Luminal Compounds Do Not Affect Butyrate Metabolism in Ulcerative Colitis

Deroover, Lise; Boesmans, Leen; Vandermeulen, Greet; Windey, Karen; Boets, Eef; Preter, Vicky De; Verbeke, Kristin

doi:10.1016/s0016-5085(15)32430-6

Cited by 1 publication

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“…It is also important to acknowledge that measurements of plasma acetate may be increased due to contamination from collection vacutainers. [ 37 ] In this study, we collected blood in EDTA‐coated tubes, in contrast to glass tubes reportedly used in the Japanese study. This may have contributed to an overestimated acetate levels.…”

Section: Discussionmentioning

confidence: 99%

Delivery of Acetate to the Peripheral Blood after Consumption of Foods High in Short‐Chain Fatty Acids

Gill

Bogatyrev

Zelm

et al. 2021

Molecular Nutrition Food Res

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Scope To promote local and systemic benefits of short‐chain fatty acids (SCFA), methods of increasing their delivery to the gastrointestinal tract are needed. SCFA in foods and beverages represents a poorly characterized source. Main aims of this study are: 1) quantify SCFA in commonly consumed foods and beverages, and 2) explore the pharmacokinetics of consuming oral SCFA from dietary sources. Methods and results Gas‐chromatography coupled to flame ionization detection is used measure SCFA in 38 commonly consumed foods and beverages. Acetate is the most abundant SCFA detected, with kombucha and vinegar found to provide >1000 mg of acetate per serve. An acute pharmacokinetic study is conducted in 10 participants. Acetate is stable across the 2‐h sampling period after consumption of a control drink, with consumption of a vinegar drink containing 25 mmol acetate significantly increasing plasma acetate concentration after 60 min and increasing acetate delivery to the blood upon assessment of the area under the pharmacokinetic curve. Conclusion Fermented foods and beverages are a natural source of dietary SCFA that acutely deliver SCFA to the blood. If systemic delivery is needed for immunological and metabolic effects to occur, these may be achieved if delivered over a longer period of time.

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Section: Discussionmentioning

confidence: 99%