Mo1712 How Frequent are Conversions of Tuberculosis (TBC) Screening Tests Among Inflammatory Bowel Disease (IBD) Patients Under Anti-TNF Treatment?

Retesting for latent tuberculosis in patients with inflammatory bowel disease treated with TNF‐α inhibitors

“…However, direct comparison of our results with this study is limited because the majority of patients in that study was tested with IGRA while on maintenance therapy with TNFi and test‐retest results prior to and during treatment were not reported. A recent report by Bermejo et al ., published only in abstract form, found almost identical results, with a rate of TST conversion of 3% (using the same definition of TST conversion) and no IGRA conversion in 67 IBD patients under TNFi treatment …”

Letter: supporting Austrian guidelines on latent tuberculosis screening

“…7 In 3 studies from Spain, 13 patients had a positive conversion in serial TST while receiving TNF-a inhibitors. [8][9][10] All the patients received 9 months of isoniazid treatment while continuing anti-TNF-a, and none of them developed active tuberculosis. We do this because in Spain, and despite all preventive actions, new cases of active TB still occur in patients on anti-TNF-a therapy.…”