Mo1463 ANALYSIS AND APPLICATION OF KEYSTONE SPECIES IN NONALCOHOLIC FATTY LIVER DISEASE BASED ON CAUSAL INFERENCE AND DYNAMIC INTERVENTION MODELING

Wu, Dingfeng; Fang, Sa; Yang, Zihuan; Jiao, Na; Gao, Wenxing; Lan, Ping; Zhu, Rong; Loomba, Rohit; Zhu, Lixin

doi:10.1016/s0016-5085(20)34199-8

Cited by 1 publication

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“…The mechanisms of NAFLD and non-alcoholic steatohepatitis (NASH) pathogenesis are not fully understood. Research on network analysis of the entire gut microbiota, not just the increase or decrease in specific bacterium, has been recently conducted for NASH pathogenesis [55]. In this study, network analysis of gut microbiome revealed that a characteristic network and the keystone bacteria differed in each group.…”

Section: The Effect Of Acn-m On Co-occurrence Network Of the Gut Micr...mentioning

confidence: 90%

Ameliorative Effects of Anthocyanin Metabolites on Western Diet-Induced NAFLD by Modulating Co-Occurrence Networks of Gut Microbiome

Nakano,

Sakao,

Wada

et al. 2023

Microorganisms

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Anthocyanins (Acn) have been reported to have preventive effects on Western diet (WD)-induced non-alcoholic fatty liver disease (NAFLD). However, the amount of Acn that reached the bloodstream were less than 1%, suggesting that anthocyanin metabolites (Acn-M) in the gut may contribute to their in vivo effects. This study is focused on a gut microbiota investigation to elucidate the effect of two major Acn-M, protocatechuic acid (PC) and phloroglucinol carboxaldehyde (PG), on NAFLD prevention. C57BL/6N male mice were divided into five groups and fed with a normal diet (ND), WD, WD + 0.5% PC, WD + 0.5% PG and WD + a mixture of 0.25% PC + 0.25% PG (CG) for 12 weeks. The results revealed that WD-fed mice showed a significant increase in final body weight, epididymis fat weight, liver weight and fat accumulation rate, serum total cholesterol, alanine aminotransferase, monocyte chemoattractant protein 1, and 2-thiobarbituric acid reactive substances. At the same time, these indices were significantly decreased by Acn-M in the order of PG, CG > PC. In particular, PG significantly decreased serum glucose and insulin resistance. Gut microbiome analysis revealed that PG significantly increased the relative abundance of Parabacteroides, Prevotella, Prevotella/Bacteroides ratio, and upregulated glucose degradation pathway. Interestingly, the co-occurrence networks of Lachnospiraceae and Desulfovibrionaceae in the PC and PG groups were similar to the ND group and different to WD group. These data suggest that PC and PG were able to recover the gut microbiome networks and functions from dysbiosis caused by WD. Therefore, PG might act as a master metabolite for anthocyanins and prevent WD-induced NAFLD and gut dysbiosis.

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Section: The Effect Of Acn-m On Co-occurrence Network Of the Gut Micr...mentioning

confidence: 90%

Ameliorative Effects of Anthocyanin Metabolites on Western Diet-Induced NAFLD by Modulating Co-Occurrence Networks of Gut Microbiome

Nakano,

Sakao,

Wada

et al. 2023

Microorganisms

View full text Add to dashboard Cite

show abstract

Mo1463 ANALYSIS AND APPLICATION OF KEYSTONE SPECIES IN NONALCOHOLIC FATTY LIVER DISEASE BASED ON CAUSAL INFERENCE AND DYNAMIC INTERVENTION MODELING

Cited by 1 publication

References 0 publications

Ameliorative Effects of Anthocyanin Metabolites on Western Diet-Induced NAFLD by Modulating Co-Occurrence Networks of Gut Microbiome

Ameliorative Effects of Anthocyanin Metabolites on Western Diet-Induced NAFLD by Modulating Co-Occurrence Networks of Gut Microbiome

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