Mo1339 Aggressive Manifestations and Grave Prognosis in Young Patients With Gastric Cancer in Thailand

Punjachaipornpon, Thanachai; Mahachai, Varocha; Vilaichone, Ratha-Korn

doi:10.1016/j.gie.2016.03.615

Cited by 2 publications

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“…The age‐standardized incidence rate of gastric cancer in Thailand was relatively low (3.1 per 100 000) compared to other Asian countries (14.3 per 100 000) 2 . However, gastric cancer ranked ninth in cancer mortality due to its grave prognosis especially in younger patients 3 . The majority of gastric cancers are adenocarcinomas 4 …”

Section: Introductionmentioning

confidence: 99%

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Prognostic factors for survival in patients with gastric adenocarcinoma

2020

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Background Gastric cancer ranks as a leading cause of cancer deaths worldwide. Information of prognostic factors related to gastric cancer are limited. Aim This study aimed to gather clinical data and prevalence of prognostic factors related to gastric adenocarcinoma in Thailand. Methods and results This retrospective cohort study was conducted at Thammasat University Hospital, Thailand between January 2010 and July 2018. Gastric adenocarcinoma patients were enrolled and followed up for at least 5 years. Total of 210 gastric tumor patients were enrolled. One hundred patients were diagnosed with gastric adenocarcinomas (57 men and 43 women, mean age = 61.1 years). The leading presenting symptoms were weight loss (65%), followed by dyspepsia (54%) and UGI bleeding. Common clinical manifestations were thrombocytosis (26%), followed by syndrome of inappropriate antidiuretic hormone (SIADH; 15%). Eosinophilia was present in early cancer (25.0% vs 6.5%, P = .123), while SIADH and thrombocytosis were more common in advanced stages (16.3% vs 0%, P = .602, and 28.3% vs 0%, P = .108, respectively). SIADH was significantly related to reduced 1‐year survival rate compared to normal serum sodium levels (21.4% vs 71.4%, OR 0.109, 95% CI 0.024‐0.497, P = .004). Five‐year survival rates were worse in patients with SIADH, but better in patients with eosinophilia compared to patients without these conditions (0% vs 27.8%, P = .058 and 20.0% vs 7.8%, P = .375, respectively). Conclusion Thrombocytosis and SIADH were common in gastric cancer. SIADH was significantly correlated with poor 1‐year survival. These clinical manifestations might be useful for predicting gastric cancer prognosis.

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Section: Introductionmentioning

confidence: 99%

“…2 However, gastric cancer ranked ninth in cancer mortality due to its grave prognosis especially in younger patients. 3 The majority of gastric cancers are adenocarcinomas. 4 Helicobacter pylori, a gram-negative rod-shaped bacterium, has been recognized as the most important factor associated with gastric cancer.…”

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confidence: 99%

Prognostic factors for survival in patients with gastric adenocarcinoma

2020

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“…Due to the low 5-year survival rate and high rate of recurrence of GC patients, as well as the fact that early diagnosis and early invention can improve the clinical outcomes of GC patients, identification and evaluation of novel biomarkers for patients with GC is of great significance [26][27][28]. In the present study, by using an RSF approach, we identified and validated a 5-gene combination (FRMD7, FLJ16779, PRR20A, SLC7A2, and SLC22A16) that could predict the survival of GC patients.…”

Section: Discussionmentioning

confidence: 99%

A 5-Gene Prognostic Combination for Predicting Survival of Patients with Gastric Cancer

Song

Wang

2019

Med Sci Monit

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Background The aim of the study was to identify a multigene prognostic factor in patients with gastric cancer (GC). Material/Methods Random survival forest (RSF) was performed to screen survival-related genes and develop a multigene combination based on the cumulative hazard function of each GC patient in TCGA-STAD and GSE15459. Kaplan-Meier curve and univariate and multivariable Cox proportional hazards regression model were applied to evaluate the prognostic performance of the 5-gene combination. C-index was used to compare the prognostic performance of the 5-gene combination and another 9-gene signature in GC. Gene set enrichment analysis (GSEA) was conducted. Results We obtained 19 survival-related genes through univariate Cox proportional hazards analysis in the training set, 5 of which were identified and were used to develop a 5-gene combination through RSF. Patients in the 5-gene combination low-risk group had better overall survival (OS) than those in the 5-gene combination high-risk group, and the 5-gene combination was demonstrated to be an independent prognostic factor in patients with GC. The 5-gene combination outperformed the 9-gene signature in predicting the OS of GC patients, and it might affect the prognosis of GC patients through E2F signaling, MYC signaling, and G2M checkpoint. Conclusions We introduce a 5-gene combination that can predict the survival of GC patients and might be an independent prognostic factor in GC.

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Mo1339 Aggressive Manifestations and Grave Prognosis in Young Patients With Gastric Cancer in Thailand

Cited by 2 publications

References 0 publications

Prognostic factors for survival in patients with gastric adenocarcinoma

Prognostic factors for survival in patients with gastric adenocarcinoma

A 5-Gene Prognostic Combination for Predicting Survival of Patients with Gastric Cancer

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