Mo1018 Associations Between Thromboelastography (TEG) and Severity of Cirrhosis

New, Stephen; Stratton, Kristin; Benson, Alexander B.; Bambha, Kiran

doi:10.1016/s0016-5085(14)63587-3

Cited by 1 publication

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“…In contrast, conventional coagulation studies did not differ between patients with cholestatic compared with non-cholestatic liver disease 14. Pihusch et al 9 observed a similar relationship; that cholestatic disease predisposes patients to a hypercoagulable state in a cohort of 37 non-cirrhotic patients with PBC or PSC compared with 53 cirrhotic patients with hepatitis C. New et al 21 also observed this hypercoagulable relationship in PBC and PSC patients in their study of 164 patients who had liver transplants.…”

Section: Discussionmentioning

confidence: 79%

Use of thromboelastography in the management of liver cirrhosis and accelerated intravascular coagulation and fibrinolysis (AICF)

Peterson¹,

Webb

Vipler

2016

BMJ Case Reports

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In the presented case, the authors describe an obese middle-aged man that presented to the emergency department for persistent oedema, scleral icterus and fatigue. He was admitted to the hospital and diagnosed with liver cirrhosis via transjugular liver biopsy. He continued to bleed from the biopsy site for 5 days from accelerated intravascular coagulation and fibrinolysis (AICF) requiring multiple transfusions of packed red blood cells, fresh-frozen plasma and cryoprecipitate. The authors then used thromboelastography (TEG) to further characterise the patient's coagulopathy, which revealed platelet inhibition. The results of the TEG significantly changed future transfusion management. Finally, the authors conducted a literature review to summarise the current literature available for the use of TEG in the management of liver cirrhosis with AICF.

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Section: Discussionmentioning

confidence: 79%