2002
DOI: 10.1046/j.1365-2958.2002.02944.x
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MntR modulates expression of the PerR regulon and superoxide resistance in Staphylococcus aureus through control of manganese uptake

Abstract: MntR modulates expression of the PerR regulon and superoxide resistance in Staphylococcus aureus through control of manganese uptake co-ordinated regulation of metal ion homeostasis and oxidative stress resistance via the regulators MntR, PerR and Fur of S. aureus is discussed. IntroductionThe acquisition of metal ions is essential for the life of all organisms. During bacterial infection, the host restricts the availability of some metal ions, such as iron. With the exception of Borrelia burgdorferi (Posey an… Show more

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Cited by 212 publications
(297 citation statements)
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“…S. aureus was grown in BHI (Oxoid), Chelex-treated BHI (CT-BHI), or CLR minimal medium at 37°C with shaking at 250 r.p.m. CLR and CT-BHI were prepared as described by Horsburgh et al (17,19). Experimental 25-ml cultures in acid-washed 250-ml flasks were incubated at a starting optical density at 600 nm (OD 600 ) of 0.01, unless otherwise stated, before growth at 37°C.…”
Section: Methodsmentioning
confidence: 99%
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“…S. aureus was grown in BHI (Oxoid), Chelex-treated BHI (CT-BHI), or CLR minimal medium at 37°C with shaking at 250 r.p.m. CLR and CT-BHI were prepared as described by Horsburgh et al (17,19). Experimental 25-ml cultures in acid-washed 250-ml flasks were incubated at a starting optical density at 600 nm (OD 600 ) of 0.01, unless otherwise stated, before growth at 37°C.…”
Section: Methodsmentioning
confidence: 99%
“…The protein concentration was measured using the method of Bradford, with bovine serum albumin as the standard (7). Screening for sensitivity to paraquat, sodium nitroprusside (SNP), SNP plus paraquat, diamide, and tellurite was performed by disk diffusion assay, as described previously (19), using CT-BHI agar without MnSO 4 . The following amounts of each stress compound were used: 50 l of 3 M paraquat, 50 l of 1 M SNP, 50 l of a 50:50 mixture of 3 M paraquat and 1 M SNP, 25 l of 1 M diamide, and 25 l of 1 M potassium tellurite.…”
Section: Methodsmentioning
confidence: 99%
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“…However, the regulation of manganese importers is slightly at odds with this model: the proton-driven manganese importer MntH is induced (by OxyR) when E. coli is exposed to H 2 O 2 (141), not O 2 − -and the ATP-driven importer MntABC is induced in Stapholococcus aureus under the same circumstances by its PerR system (142). Further, mutations that eliminate these systems sensitize a variety of microbes to H 2 O 2 (143) (141).…”
Section: How Does Manganese Protect Microbes Against Oxidative Stress?mentioning
confidence: 99%
“…but does accumulate Mn (Mn accumulation was severely impaired in the bmtA mutant), (ii) Mn is believed to be involved in the oxidative stress response of a number of pathogens (17,31,32), and (iii) Bb SodA (BB0153) has been predicted to be Mn-dependent (22, 33), we explored whether the inactivation of bmtA adversely impacted Bb's ability to detoxify intracellular superoxide. When WT 297 was exposed to 5 mM or 10 mM t-butyl hydroperoxide, Ϸ100% or 93%, respectively, of the cells survived (Fig.…”
Section: Bmta Is Important For Protecting Bb Against Reactive Oxygen mentioning
confidence: 99%