Mn<sub>++</sub> BINDING BY PLASMA PROTEINS

Nandedkar, Arvind K.N.; Nurse, Clotelle E.; Friedberg, Felix

doi:10.1111/j.1399-3011.1973.tb03462.x

Cited by 34 publications

(5 citation statements)

References 8 publications

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“…Additionally, if Mn is adsorbed on the surface of the MTPLs, this Mn contrast agent would induce a small positive enhancement without heating and partially behave as a liposome marker, independent of membrane destabilization. However, as mentioned previously, the released Mn 21 will rapidly become trapped in the surrounding tissues, [32][33][34] and the doxorubicinMn 21 complexes may act predominantly as an actual drug marker. Therefore, even if the distributions of Mn and doxorubicin are not perfectly identical, the thermotriggered alteration in signal can be used as a macroscopic marker for the release of the substances.…”

Section: Discussionmentioning

confidence: 99%

“…Second, after release from the liposomes, Mn 21 can rapidly bind albumin or other proteins in the tissue and be retained near the release site. [32][33][34] Third, Mn 21 -albumin or Mn 21 -protein complexes can enhance T 1 relaxivity through the slow molecular moving. [35][36][37] Thus, Mn 21 is an appropriate MRI contrast agent for the design of a thermosensitive, polymer-based, activatable liposomal DDS.…”

Section: Translational Significancementioning

confidence: 99%

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Thermoactivatable polymer-grafted liposomes for low-invasive image-guided chemotherapy

Aoki¹,

Yoneyama²,

Hirose

et al. 2015

Translational Research

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Section: Discussionmentioning

confidence: 99%

Section: Translational Significancementioning

confidence: 99%

Thermoactivatable polymer-grafted liposomes for low-invasive image-guided chemotherapy

Aoki¹,

Yoneyama²,

Hirose

et al. 2015

Translational Research

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“…However, whether Mn can influence the development of DR through other metabolic pathways has yet to be investigated. In plasma, approximately 80% of the oxidized state of Mn 2+ is bound to ALB and globulin and transported to the liver, kidney, small intestine, endocrine glands, pancreas, brain, bone, muscle, and hair 12,28 . ALB is a glycosylated protein synthesized and secreted by hepatocytes, which has anti-oxidative stress and anti-inflammatory 29 .…”

Section: Discussionmentioning

confidence: 99%

Association between serum heavy metal levels and diabetic retinopathy in NHANES 2011–2020

Zhang,

Liu,

Zhang

et al. 2024

Sci Rep

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The present study utilized the National Health and Nutrition Examination Survey (NHANES) database to examine the relationship between serum levels of heavy metals and Diabetic retinopathy (DR) in individuals aged over 30 years with type 2 diabetes mellitus (T2DM) in the United States. A cross-sectional analysis was conducted on 1583 individuals with T2DM from the NHANES 2011–2020, including 331 individuals in the DR group and 1252 individuals in the non-DR group. We collected data on serum levels of heavy metals, DR, and serum albumin for descriptive statistics, linear regression, and logistical regression analysis. After adjusting for age, gender, race and other factors, there was no statistically significant association between blood cadmium, selenium, mercury, or lead and DR. However, serum manganese (Mn) and DR had a significant negative association (β = − 0.2045, 95% CI = − 0.3484, − 0.0606). Serum albumin partially modulated the indirect influence of serum Mn on the incidence of DR, accounting for 12.80% of the association between serum Mn and DR. There was a negative association between serum Mn levels and the prevalence of DR in people with T2DM. Mn intake at least in this study has a little influence on the onset and development of DR.

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“…1975) and Ni2+ is also bound to albumin in vitro (Rao 1962;Callan & Sunderman 1973;Nandedkar et al 1973). After the administration of 63Ni(C0)4, more 63Ni is present in the erythrocytes than in the serum at short survival intervals (Oskarsson & Tjalve 1979b).…”

Section: Discussionmentioning

confidence: 99%

Binding of ⁶³Ni by Cellular Constituents in Some Tissues of Mice after the Administration of ⁶³NiCl₂ and ⁶³Ni(CO)₄

Oskarsson

Tjälve

1979

Acta Pharmacologica et Toxicologica

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One and 24 hours after the administration of6'NiC12 and 63Ni(C0)4 to mice 63Ni was present in association with both particulate and soluble cellular constituents in the lung, liver and kidney. After disruption of the cellular organells by sonication, a considerable part of the 6'Ni was still bound to the cellular fragments.Sephadex G-75 chromatography of the cytosol of the lung showed that the largest proportion of 63Ni was eluted in the void volume and a smaller proportion was present in the salt volume. In the kidney, the proportions were reversed. Twentyfour hours after the injection of 63NiC12 an intermediate 63Ni-containing peak, with an estimated molecular weight of about 30,000, was found in the lung and the kidney. In the liver of 6'NiC1~-injected mice, most of the nickel was recovered in the void volume, a lesser amount in the salt volume. There was no evidence that 63Ni was bound to metallothionein (induced by Cd-pretreatment) or to superoxide dismutase in the studied tissues. Pretreatments with non-labelled NiC12 did not alter the elution profiles. In serum, most 6'Ni was present in association with albumin. Gel-chromatograms of red blood-cell hemolysates from 63Ni(CO)sinjected mice showed 61Ni at an elution volume corresponding to hemoglobin, but 6'Ni-binding ligands with higher and lower molecular weights were also present.

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Mn₊₊ BINDING BY PLASMA PROTEINS

Cited by 34 publications

References 8 publications

Thermoactivatable polymer-grafted liposomes for low-invasive image-guided chemotherapy

Thermoactivatable polymer-grafted liposomes for low-invasive image-guided chemotherapy

Association between serum heavy metal levels and diabetic retinopathy in NHANES 2011–2020

Binding of ⁶³Ni by Cellular Constituents in Some Tissues of Mice after the Administration of ⁶³NiCl₂ and ⁶³Ni(CO)₄

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Mn++ BINDING BY PLASMA PROTEINS

Cited by 34 publications

References 8 publications

Thermoactivatable polymer-grafted liposomes for low-invasive image-guided chemotherapy

Thermoactivatable polymer-grafted liposomes for low-invasive image-guided chemotherapy

Association between serum heavy metal levels and diabetic retinopathy in NHANES 2011–2020

Binding of 63Ni by Cellular Constituents in Some Tissues of Mice after the Administration of 63NiCl2 and 63Ni(CO)4

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Mn₊₊ BINDING BY PLASMA PROTEINS

Binding of ⁶³Ni by Cellular Constituents in Some Tissues of Mice after the Administration of ⁶³NiCl₂ and ⁶³Ni(CO)₄