Mn(<scp>ii</scp>) complex impregnated porous silica nanoparticles as Zn(<scp>ii</scp>)-responsive “Smart” MRI contrast agent for pancreas imaging

Mukherjee, Chandan; Mallik, Riya; Saha, Muktashree; Saini, Hari Mohan; Kumaran, Senthil; Singh, Vivek

doi:10.1039/d3tb01289a

Cited by 2 publications

(1 citation statement)

References 66 publications

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“…A similar experiment was done for the wellestablished mono(aquated) Mn(EDTA) and Mn(AlcDPA) complexes. 45,46 The slope for Complex 1 was found to be ∼2fold higher than that for the previously reported mono-(aquated) complexes, suggesting the presence of two metalcoordinated water molecules in Complex 1. 47 Moreover, at the identical experimental conditions, the paramagnetic resonance signal for the synthesized complex solution was vividly broader than that of the monoaquated Mn(AlcDPA) complex indicating the presence of more than one water molecule in the inner coordination sphere.…”

Section: ■ Results and Discussionmentioning

confidence: 58%

A Bis(Aquated) Mn(II)-Based MRI Contrast Agent with a Rigid Hydroquinazoline Unit: Synthesis, Characterization, and in Vivo MR Imaging Study

Mallik,

Saha,

Sarmah

et al. 2024

ACS Appl. Bio Mater.

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Since the finding of nephrogenic systemic fibrosis (NFS) in patients with renal impairment and the long-term accumulation of Gd(III) ions in the central nervous system, the search for nongadolinium ion-based MRI contrast agents made of nutrient metal ions has drawn paramount attention. In this context, the development of Mn(II)-based MRI contrast agents has been a subject of interest for the last few decades. Herein, we report a pentadentate ligand (Li2[BenzPic2]) composed of two picolinate moieties and a rigid 1,2,3,4-tetrahydroquinazoline unit and the corresponding bis(aquated) Mn(II) complex (Complex 1). The complex exhibited high thermodynamic stability (log K cond = 11.62) and kinetic inertness similar to that of the clinically approved Gd(III)-based contrast agent Magnevist. Complex 1 exerted longitudinal relaxivity (r 1) of 5.32 mM–1 s–1 at 1.41 T, 37 °C, pH 7.4, and it increased by 3.6-fold in the presence of serum albumin protein, confirming a substantial rigidifying interaction (albumin association constant K A = 1.66 × 103 M–1) between the protein and the amphiphilic (log P = −0.45) contrast agent. An intravenous dose of 0.08 mmol/kg in a healthy mouse, excellent MRI signal intensity enhancement in the vasculature of the mouse liver, and brightened images of the gallbladder, kidney, and liver were realized.

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Section: ■ Results and Discussionmentioning

confidence: 58%

A Bis(Aquated) Mn(II)-Based MRI Contrast Agent with a Rigid Hydroquinazoline Unit: Synthesis, Characterization, and in Vivo MR Imaging Study

Mallik,

Saha,

Sarmah

et al. 2024

ACS Appl. Bio Mater.

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Folate Receptor Targeting Mn(II) Complex Encapsulated Porous Silica Nanoparticle as an MRI Contrast Agent for Early‐State Detection of Cancer

Mallik,

Saha,

Ghosh

et al. 2024

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Cancer is recognized as one of the major causes of mortality, however, early‐stage detection can increase the survival chance greatly. It is recognized that folate receptors are gradually overexpressed in the cellular membrane with the progress of cancer from stage 1 to stage 4. Utilizing the fact, herein, developed a porous silica nanoparticle system C1@SiO2–FA–NP; A) impregnated with thermodynamically stable Mn(II) complex (1) molecules within the core of the nanoparticle, and B) surface functionalized with folate units. It exhibited a high longitudinal relaxivity value r1 = 21.45 mM−1s−1 that substantially increased to r1 = 40.97 mM−1s−1 in the presence of 0.67 mM concentration of BSA under the physiological condition. The in vitro fluorescent images after surface conjugation of C1@SiO2–FA–NP with FITC (fluorescein isothiocyanate) buttressed the inclusion of the nanoparticle exclusively within the cancerous HeLa cells than that of healthy HEK293 cells. The importance of the surface‐bound folate unit in the nanoparticle is further established by comparing the fluorescent images of HeLa cells in the absence of the group. Finally, the applicability of C1@SiO2–FA–NP as the T1‐weighted MRI contrast agent for early‐stage cancer diagnosis is established within C57BL/6 mice after infecting the mice with HeLa cells.

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Mn(ii) complex impregnated porous silica nanoparticles as Zn(ii)-responsive “Smart” MRI contrast agent for pancreas imaging

Abstract: Type-1 and Type-2 diabetes mellitus are metabolic disorders governed by the functional efficiency of pancreatic -cells. The activities of the cells toward insulin production, storage, and secretion are accompanied by...

Cited by 2 publications

References 66 publications

A Bis(Aquated) Mn(II)-Based MRI Contrast Agent with a Rigid Hydroquinazoline Unit: Synthesis, Characterization, and in Vivo MR Imaging Study

A Bis(Aquated) Mn(II)-Based MRI Contrast Agent with a Rigid Hydroquinazoline Unit: Synthesis, Characterization, and in Vivo MR Imaging Study

Folate Receptor Targeting Mn(II) Complex Encapsulated Porous Silica Nanoparticle as an MRI Contrast Agent for Early‐State Detection of Cancer

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