Mn-doped Ti-based MOFs for magnetic resonance imaging-guided synergistic microwave thermal and microwave dynamic therapy of liver cancer

Qin, Qiongyu; Yang, Ming; Shi, Yu; Cui, Haijing; Pan, Chunshu; Ren, Wenzhi; Wu, Aiguo; Hu, Jinqiu

doi:10.1016/j.bioactmat.2023.03.019

Cited by 10 publications

(5 citation statements)

References 51 publications

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“…Microwave thermotherapy (MWT) is a kind of treatment that utilizes microwave (MW) irradiation to induce thermal damage of tumors. − Owing to the advantages of high penetrating ability and small trauma, it has been applied to the clinical treatment of multitype cancer . However, the nonselectivity of MW irradiation makes it still a challenge to completely ablate a tumor lesion while ensuring the safety of adjacent normal tissue, especially for these large or irregularly shaped tumors, ultimately resulting in tumor residual and recurrence .…”

Section: Introductionmentioning

confidence: 99%

Magnetic Bimetallic Heterointerface Nanomissiles with Enhanced Microwave Absorption for Microwave Thermal/Dynamics Therapy of Breast Cancer

Yu,

Li,

Ren

et al. 2024

ACS Nano

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Microwave thermotherapy (MWT) has shown great potential in cancer treatment due to its deep tissue penetration and minimally invasive nature. However, the poor microwave absorption (MA) properties of the microwave thermal sensitizer in the medical frequency band significantly limit the thermal effect of MWT and then weaken the therapeutic efficacy. In this paper, a Ni-based multilayer heterointerface nanomissile of MOFs-Ni-Ru@COFs (MNRC) with improved MA performance in the desired frequency band via introducing magnetic loss and dielectric loss is developed for MWT-based treatment. The loading of the Ni nanoparticle in MNRC mediates the magnetic loss, introducing the MA in the medical frequency band. The heterointerface formed in the MNRC by nanoengineering induces significant interfacial polarization, increasing the dielectric loss and then enhancing the generated MA performance. Moreover, MNRC with the strong MA performance in the desired frequency range not only enhances the MW thermal effect of MWT but also facilitates the electron and energy transfer, generating reactive oxygen species (ROS) at tumor sites to mediate microwave dynamic therapy (MDT). The strategy of strengthening the MA performance of the sensitizer in the medical frequency band to improve MWT-MDT provides a direction for expanding the clinical application of MWT in tumor treatment.

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Section: Introductionmentioning

confidence: 99%

Magnetic Bimetallic Heterointerface Nanomissiles with Enhanced Microwave Absorption for Microwave Thermal/Dynamics Therapy of Breast Cancer

Yu,

Li,

Ren

et al. 2024

ACS Nano

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“…Traditional MAMs include magnetic metal particles − and ferrites, − which primarily rely on magnetic loss, and metal oxides, ,, carbides, , and carbon-based materials, ,− which primarily rely on dielectric loss. In order to pursue better MA effects, researchers have successively developed cutting-edge materials in the field of MA, such as topological insulator MAMs, nanoporous metal organic framework (MOF) MAMs, two-dimensional transition metal sulfide composites, magneto-optical composites, and 3D carbon materials …”

Section: Introductionmentioning

confidence: 99%

Review of Three-Dimensional Graphene and Related Composite Materials for Microwave Absorption

Liu,

Wang,

Wei

et al. 2024

ACS Appl. Nano Mater.

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With the development of modern society and technology, increased levels of electromagnetic pollution have created a greater demand for advanced electromagnetic wave absorption materials for use in both civilian and military applications. Three-dimensional graphene (3DG) has excellent potential for use in the field of microwave absorption (MA) due to its unique porous network structure, low density, and large specific surface area. However, the dielectric loss performance will lead to poor impedance matching performance, making it unsuitable for use as a single absorber. To overcome this shortcoming, 3DG-based composites have been developed by combining 3DG with other absorbing materials to create structures with improved impedance matching performance and absorption efficiency. Compared to other review articles, this Review comprehensively summarizes the preparation methods of 3DG and discusses the advantages and disadvantages of various methods. Subsequently, based on the types of composite materials, the research progress of 3DG-based composite absorptive materials is discussed. Finally, the obstacles to the widespread application of composite absorptive materials based on 3DG are summarized along with future research directions. Finally, the barriers to the widespread use of 3DG-based composite absorbing materials and future research directions are summarized.

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“…[31][32][33][34][35] Regarding MDT, Chen et al reported that TiO 2 nanoparticles can induce plasma effects and generate ROS upon microwave irradiation. [35][36][37][38][39] However, the catalytic efficiency of single-metal microwave dynamic agents is limited. 40,41 Compared with monometallic MOF structures, bimetallic MOFs have more catalytic active sites and faster catalytic rates, making these materials more conducive to efficient electron transfer within the framework and between substrates and thus improving the microwave dynamic efficiency under microwave irradiation.…”

Section: Introductionmentioning

confidence: 99%

Fe-doped Cu-based bimetallic metal–organic frameworks as nanoscale microwave sensitizers for enhancing microwave thermal and dynamic therapy for hepatocellular carcinoma

Luo,

Sun,

et al. 2024

Nanoscale

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Mn-doped Ti-based MOFs for magnetic resonance imaging-guided synergistic microwave thermal and microwave dynamic therapy of liver cancer

Cited by 10 publications

References 51 publications

Magnetic Bimetallic Heterointerface Nanomissiles with Enhanced Microwave Absorption for Microwave Thermal/Dynamics Therapy of Breast Cancer

Magnetic Bimetallic Heterointerface Nanomissiles with Enhanced Microwave Absorption for Microwave Thermal/Dynamics Therapy of Breast Cancer

Review of Three-Dimensional Graphene and Related Composite Materials for Microwave Absorption

Fe-doped Cu-based bimetallic metal–organic frameworks as nanoscale microwave sensitizers for enhancing microwave thermal and dynamic therapy for hepatocellular carcinoma

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