Mn-containing titanium surface with favorable osteogenic and antimicrobial functions synthesized by PIII&amp;D

Yu, Le; Tian, Yuan; Qiao, Yan; Liu, Xuanyong

doi:10.1016/j.colsurfb.2017.01.047

Cited by 49 publications

(25 citation statements)

References 33 publications

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“…Higher osteoblast-like cell-adhesion was observed on Mn-containing hydroxyapatites [27], compared to synthetic HA, and tricalcium phosphates containing this ion presented higher bone mineralisation rates [28]. An increase in the osteogenesis-related gene expression and collagen deposition rate was observed in Mn-containing titanium implants exposed to rat bone marrow mesenchymal stem cells [29]; an increased antibacterial activity was also observed in multifunctional materials containing this ion [29,30]. Melt-derived BGs containing Mn promoted alkaline phosphatase activity (ALP) and BMP expression in osteoblast culture, and presented good osteoblast proliferation and spreading [25].…”

Section: Introductionmentioning

confidence: 99%

Osteogenic potential of sol–gel bioactive glasses containing manganese

Barrioni

Norris

et al. 2019

J Mater Sci: Mater Med

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We report that the release of manganese ions from bioactive glass provoked human mesenchymal stem cell (hMSC) differentiation down a bone pathway, whereas hMSCs exposed to the Mn-free glass did not differentiate. Bioactive glasses (BGs) are widely used for bone regeneration, and allow the incorporation of different ions with therapeutic properties into the glass network. Amongst the different ions with therapeutic benefits, manganese (Mn) has been shown to influence bone metabolism and activate human osteoblasts integrins, improving cell adhesion, proliferation and spreading. Mn has also been incorporated into bioceramics as a therapeutic ion for improved osteogenesis. Here, up to 4.4 mol% MnO was substituted for CaO in the 58S composition (60 mol% SiO2, 36 mol% CaO, 4 mol% P2O5) and its effects on the glass properties and capability to influence the osteogenic differentiation were evaluated. Mncontaining BGs with amorphous structure, high specific surface area and nanoporosity were obtained. The presence of Mn 2+ species was confirmed by X-ray photoelectron spectroscopy (XPS). Mn-containing BGs presented no cytotoxic effect on human mesenchymal stem cells (hMSCs) and enabled sustained ion release in culture medium. hMSCs osteogenic differentiation stimulation and influence on the mineralisation process was also confirmed through the alkaline phosphatase (ALP) activity, and expression of osteogenic differentiation markers, such as collagen type I, osteopontin and osteocalcin, which presented higher expression in the presence of Mn-containing samples compared to control. Mn incorporation offers great promise for obtaining glasses with superior properties for bone tissue regeneration.

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Section: Introductionmentioning

confidence: 99%

Osteogenic potential of sol–gel bioactive glasses containing manganese

Barrioni

Norris

et al. 2019

J Mater Sci: Mater Med

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“…The samples were finally dried against a series of HMDS solutions diluted in ethanol (33, 50, 67, and 100% [vol/vol]) after the final dehydration. (Yu, Tian, Qiao, & Liu, 2017)…”

Section: Methodsmentioning

confidence: 99%

Effect of three‐dimensional porosity gradients of biomimetic coatings on their bonding strength and cell behavior

Santisteban

Liu

et al. 2020

J Biomedical Materials Res

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Surface modification techniques are often used to enhance the properties of Ti‐based materials as hard‐tissue replacements. While the microstructure of the coating and the quality of the interface between the substrate and coating are essential to evaluate the reliability and applicability of the surface modification. In this study, both a hydroxyapatite (HA) coating and a collagen‐hydroxyapatite (Col‐HA) composite coating were deposited onto a Ti‐6Al‐4V substrate using a biomimetic coating process. Importantly, a gradient cross‐sectional structure with a porous coating toward the surface, while a dense layer adjacent to the interface between the coating and substrate was observed in three‐dimensional (3D) from both the HA and Col‐HA coatings via a dual‐beam focused ion beam‐scanning electron microscope (FIB‐SEM). Moreover, the pore distributions within the entire coatings were reconstructed in 3D using Avizo, and the pores size distributions along the coating depth were calculated using RStudio. By evaluating the mechanical property and biocompatibility of these materials and closely observing the cross‐sectional cell‐coating‐substrate interfaces using FIB‐SEM, it was revealed that the porous surface created by both coatings well supports osteoblast cell adhesion while the dense inner layer facilitates a good bonding between the coating and the substrate. Although the mechanical property of the coating decreased with the addition of collagen, it is still strong enough for implant handling and the biocompatibility was promoted.

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“…In a similar study, manganese (Mn) doped Ca-P/TiO 2 (Mn- Ca-P/TiO 2 ) was fabricated through a one-step MAO technique to evaluate the antimicrobial efficiency against Staphylococcus aureus [107] . Mn is one of the significant elements needed for bone growth, bone metabolism, synthesis of essential enzymes, and cellular homeostasis [108] .…”

Section: Recent Advancesmentioning

confidence: 99%