MMR vaccination in England falls below critical threshold

Kirby, Tony

doi:10.1016/s1473-3099(22)00169-4

Cited by 3 publications

(2 citation statements)

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“…According to recent data from the United Kingdom, for example, delays were observed as far as the anti-Measles-Mumps-Rubella (MMR) paediatric vaccination is concerned. This has caused MMR coverage to plummet below 90%, leading to an increase in the risk of Measle epidemics (32).…”

Section: Discussionmentioning

confidence: 99%

Allergic adverse events following immunization: Data from post-marketing surveillance in Apulia region (South of Italy)

et al. 2023

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IntroductionAmong adverse events following immunization (AEFIs), allergic reactions elicit the most concern, as they are often unpredictable and can be life-threatening. Their estimates range from one in 1,000,000 to one in 50,000 vaccine doses. This report describes allergic events following immunization reported from 2020 to 2021 in Puglia, a region in the South-East of Italy with around 4 million inhabitants. Its main objective is to describe the allergic safety profile of currently employed vaccines.Materials and methodsThis is a retrospective observational study. The study period spanned from January 2020 to December 2021, and the whole Apulian population was included in the study. Information regarding AEFIs reported in Puglia during the study period was gathered from the Italian Drug Authority’s pharmacovigilance database (National Pharmacovigilance Network, RNF). The overall number of vaccine doses administered was extrapolated by the Apulian online immunization database (GIAVA). Reporting rates were calculated as AEFIs reported during a certain time span/number of vaccine doses administered during the same period.Results10,834,913 vaccine doses were administered during the study period and 95 reports of allergic AEFIs were submitted to the RNF (reporting rate 0.88/100,000 doses). 27.4% of the reported events (26/95) were classified as serious (reporting rate 0.24/100,000 doses). 68 out of 95 (71.6%) adverse events were at least partially resolved by the time of reporting and none of them resulted in the subject’s death.ConclusionsAllergic reactions following vaccination were rare events, thus confirming the favourable risks/benefits ratio for currently marketed vaccines.

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Section: Discussionmentioning

confidence: 99%

Allergic adverse events following immunization: Data from post-marketing surveillance in Apulia region (South of Italy)

et al. 2023

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“…Primary prevention services such as immunisation and cancer screening have a substantial impact on morbidity and mortality [ 1 ], and lack of access or delays to these services will have important negative consequences over time for both individuals and the population, and potentially lead to inequalities. For example, over the last few years, the UK has experienced increases in vaccine preventable illness such as Measles, Mumps and Rubella [ 2 , 3 ]. Many have discussed how delays in vaccination will lead to future outbreaks of pertussis [ 4 ], chickenpox [ 5 , 6 ] and meningitis [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Learning from the universal, proactive outreach of the Brazilian Community Health Worker model: impact of a Community Health and Wellbeing Worker initiative on vaccination, cancer screening and NHS health check uptake in a deprived community in the UK

Junghans,

Antonacci,

Williams

et al. 2023

BMC Health Serv Res

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Background Delays in preventative service uptake are increasing in the UK. Universal, comprehensive monthly outreach by Community Health and Wellbeing Workers (CHW), who are integrated at the GP practice and local authority, offer a promising alternative to general public health campaigns as it personalises health promotion and prevention of disease holistically at the household level. We sought to test the ability of this model, which is based on the Brazilian Family Health Strategy, to increase prevention uptake in the UK. Methods Analysis of primary care patient records for 662 households that were allocated to five CHWWs from July 2021. Primary outcome was the Composite Referral Completion Indicator (CRCI), a measure of how many health promotion activities were received by members of a household relative to the ones that they were eligible for during the period July 2021-April 2022. The CRCI was compared between the intervention group (those who had received at least one visit) and the control group (allocated households that were yet to receive a visit). A secondary outcome was the number of GP visits in the intervention and control groups during the study period and compared to a year prior. Results Intervention and control groups were largely comparable in terms of household occupancy and service eligibilities. A total of 2251 patients in 662 corresponding households were allocated to 5 CHWs and 160 households had received at least one visit during the intervention period. The remaining households were included in the control group. Overall service uptake was 40% higher in the intervention group compared to control group (CRCI: 0.21 ± 0.15 and 0.15 ± 0.19 respectively). Likelihood of immunisation uptake specifically was 47% higher and cancer screening and NHS Health Checks was 82% higher. The average number of GP consultations per household decreased by 7.4% in the intervention group over the first 10 months of the pilot compared to the 10 months preceding its start, compared with a 0.6% decrease in the control group. Conclusions Despite the short study period these are promising findings in this deprived, traditionally hard to reach community and demonstrates potential for the Brazilian community health worker model to be impactful in the UK. Further analysis is needed to examine if this approach can reduce health inequalities and increase cost effectiveness of health promotion approaches.

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The societal cost of vaccine refusal: A modelling study using measles vaccination as a case study

Mesa

Winskill

Ghani

et al. 2023

Vaccine

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MMR vaccination in England falls below critical threshold

Cited by 3 publications

References 0 publications

Allergic adverse events following immunization: Data from post-marketing surveillance in Apulia region (South of Italy)

Allergic adverse events following immunization: Data from post-marketing surveillance in Apulia region (South of Italy)

Learning from the universal, proactive outreach of the Brazilian Community Health Worker model: impact of a Community Health and Wellbeing Worker initiative on vaccination, cancer screening and NHS health check uptake in a deprived community in the UK

The societal cost of vaccine refusal: A modelling study using measles vaccination as a case study

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