Mmp2 Deficiency Leads to Defective Parturition and High Dystocia Rates in Mice
Rotem Kalev-Altman,
Gal Becker,
Tamar Levy
et al.
Abstract:Parturition is the final and essential step for mammalian reproduction. While the uterus is quiescent during pregnancy, fundamental changes arise in the myometrial contractility, inducing fetal expulsion. Extracellular matrix (ECM) remodeling is fundamental for these events. The gelatinases subgroup of matrix metalloproteinases (MMPs), MMP2 and MMP9, participate in uterine ECM remodeling throughout pregnancy and parturition. However, their loss-of-function effect is unknown. Here, we determined the result of e… Show more
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