MMP13, TIMP2 and TGFB3 Gene Polymorphisms in Brazilian Chronic Periodontitis and Periimplantitis Subjects

Abstract

Subjects susceptible to chronic periodontitis (CP) show a high risk for the development of peiimplantitis (PI). Both diseases are multifactorial, presenting similarities in their pathophysiology and polygenic profile. MMP-13 (matrix metalloproteinases 13/ collagenase 3) is a collagenolytic enzyme, which expression is induced by TGF beta 3 (transforming growth factor type 3) in human gingival fibroblasts and inhibited by TIMP-2 (tissue inhibitor of metalloproteinase type 2). The aim of this study was to investigate the occurrence of peiimplantitis (PI) in subjects with history of chronic periodontitis (CP) and polymorphisms frequency in MMP13, TIMP2 and TGFB3 genes. One hundred and sixty-three volunteers received dental implant placement were submitted to oral and radiographic examination in order to identify past history of CP or presence of PI. Volunteers were divided into 4 groups: Control (without PI and CP, n=72), CP (with CP and without PI, n=28), PI (with PI and without CP, n=28) and diseased (with CP and PI, n=35). The chi-square test correlated genotypes in specific regions of MMP13 (rs2252070), TIMP2 (rs7501477) and TGFB3 (rs2268626) genes, considering the interaction between CP and PI. The results showed that volunteers with CP had 3.2 times more susceptibility to develop PI (p=0.0004) compared to those without CP. No significant association was observed in MMP13, TIMP2 and TGFB3 genes with CP or PI. CP is a risk factor to develop PI, however, there is no association of both diseases with polymorphisms in the MMP13, TIMP2 and TGFB3 genes. M M P 1 3 , T I M P 2 a n d T G F B 3 G e n e P o l y m o r p h i s m s i n Brazilian Subjects with Chronic Periodontitis and Periimplantitis

Association of IL-6, IL-8, MMP-13 gene polymorphisms with knee osteoarthritis susceptibility in the Chinese Han population

“…Studies have reported that non-physiological mechanical stress caused by joint deformities can up-regulate the expression of interleukin (IL) 6 (IL-6), IL-8, and matrix metalloproteinase-13 (MMP-13) in the callus and is potentially involved in OA progression [9]. Single nucleotide polymorphisms (SNPs) in the genes encoding IL-6 [10], IL-8 [11], and MMP-13 [12] have been associated with the occurrence of various diseases. However, few studies have investigated the occurrence of OA.…”

Evaluation of collagenase-3 matrix metalloproteinase-13 gene-associated polymorphisms 11A/12A and −77A/G and its associated alleles with and without periodontitis

“…[6] However, reciprocal results were found in relation with MMP-13 and CP. [1213] There is no clear-cut literature review pertaining to periodontitis and MMP-13 gene polymorphisms (−77A/G and 11A/12A) and MMP-13 genotypes (GTs) (11A/12A, 11A/11A, and 12A/12A) and (AA, AG, GG). In consequence, the intent of the present study was to investigate MMP-13 gene polymorphisms (−77A/G and 11A/12A) and further to determine the association between MMP-13 GTs (11A/12A, 11A/11A, 12A/12A) and (AA, AG, and GG) along with associated alleles (11A, 12A, A, and G) in whole blood of the individuals with CP and without periodontitis.…”