MMP-9 responsive dipeptide-tempted natural protein hydrogel-based wound dressings for accelerated healing action of infected diabetic wound

Sonamuthu, Jegatheeswaran; Cai, Yurong; Liu, Han; Subarkhan, Mohamed Kasim Mohamed; Vasanthakumar, Vasantha Ruban; Pandi, Boomi; Wang, Hangxiang; Yao, Juming

doi:10.1016/j.ijbiomac.2019.10.236

Cited by 99 publications

(53 citation statements)

References 73 publications

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“…Histological analysis is a powerful method to observe the progress in healing and tissue regeneration of wounds (Sonamuthu et al, 2020). Histological analysis focused on the healing ability of injured mice tissues due to the influence of hematoxylin and eosin (H&E) staining on the Ce-nGel (control) and Ce-nGel-Glu (Figure 8).…”

Section: Histological Evaluationmentioning

confidence: 99%

RETRACTED ARTICLE: Cerium oxide nanoparticle-loaded polyvinyl alcohol nanogels delivery for wound healing care systems on surgery

et al. 2021

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This study was designed to establish the composition of wound bandages based on Cerium nanoparticle (CeNP)-loaded polyvinyl alcohol (PVA) nanogels. The CeNP nanogel (Ce-nGel) was fabricated by the fructose-mediated reduction of Cerium oxide solutions within the PVA matrix. The influences of different experimental limitations on PVA nanogel formations were examined. The nanogel particle sizes were evaluated by transmission electron microscopy and determined to range from $10 to 50 nm. Additionally, glycerol was added to the Ce-nGels, and the resulting compositions (Ce-nGel-Glu) were coated on cotton fabrics to generate the wound bandaging composite. The cumulative drug release profile of the Cerium from the bandage was found to be $38% of the total loading after two days. Additionally, antibacterial efficacy was developed for Gam positive and negative microorganisms. Moreover, we examined in vivo healing of skin wounds formed in mouse models over 24 days. In contrast to the untreated wounds, rapid healing was perceived in the Ce-nGel-Glu-treated wound with less damage. These findings indicate that Ce-nGel-Glu-based bandaging materials could be a potential candidate for wound healing applications in the future.

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Section: Histological Evaluationmentioning

confidence: 99%

RETRACTED ARTICLE: Cerium oxide nanoparticle-loaded polyvinyl alcohol nanogels delivery for wound healing care systems on surgery

et al. 2021

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“…The ideal hydrogel for wound dressing should also possess appropriate mechanical strength, controllable swelling, antibacterial behavior, tissue adhesion, hemostasis, biocompatibility, effective tissue regeneration ability and resistance against microbial infection, along with low cost, convenient storage and transportation, etc. 5,111,112 The SD rat model with full-thickness skin defects and other characterization techniques have been employed to evaluate the wound healing ability of the hydrogels. It is believed that the hydrogels with optimal mechanical strength can accelerate the blood coagulation, reduce blood loss and promote wound healing.…”

Section: Wound Healingmentioning

confidence: 99%

“…Thus, the hydrogels dressing with anti-inflammatory, antibacterial and antioxidant properties can cure these wounds more effectively. Jegatheeswaran Sonamuthu et al 111 used anti-inflammatory curcumin (cur) and SF to prepare the hydrogels, loaded with the metal chelating dipeptide (L-carnosine) with antioxidant and anti-inflammatory functions. The resulting L-car@cur/SF hydrogel demonstrated MMP responsiveness and effectively inactivated the MMP-9 matrix metalloproteinase.…”

Section: Wound Healingmentioning

confidence: 99%

Functional silk fibroin hydrogels: preparation, properties and applications

2021

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“…The experimental protocol was followed according to the previously reported article. 56 In brief, streptozotocin was injected to an intraabdominal place of BALB/c mice at a dose of 75 mg/kg to create diabetes mellitus. After 2 days, the blood glucose levels were monitored by using Glucometer and the glucose level of 21.3 mmol/L was noticed.…”

Section: In Vivo Evaluation Of the Wound-healing Activitymentioning

confidence: 99%

<p>Phyto-Engineered Gold Nanoparticles (AuNPs) with Potential Antibacterial, Antioxidant, and Wound Healing Activities Under in vitro and in vivo Conditions</p>

Boomi

Ganesan²,

Poorani³

et al. 2020

IJN

102

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Background: A diabetic ulcer is one of the major causes of illness among diabetic patients that involves severe and intractable complications associated with diabetic wounds. Hence, a suitable wound-healing agent is urgently needed at this juncture. Greener nanotechnology is a very promising and emerging technology currently employed for the development of alternative medicines. Plant-mediated synthesis of metal nanoparticles has been intensively investigated and regarded as an alternative strategy for overcoming various diseases and their secondary complications like microbial infections. Hence, we are interested in developing phyto-engineered gold nanoparticles as useful therapeutic agents for the treatment of infectious diseases and wounds effectively. Methods and Results: We have synthesized phyto-engineered gold nanoparticles from the aqueous extract of Acalypha indica and characterized using advanced bio-analytical techniques. The surface plasmon resonance feature and crystalline behavior of gold nanoparticles were revealed by ultraviolet-visible spectroscopy and X-ray diffraction, respectively. High-performance liquid chromatography analysis of the extract demonstrated the presence of different constituents, while major functional groups were interpreted by the Fourier-transform infrared spectroscopy as the various stretching vibrations appeared for important O-H (3443 cm −1), C=O (1644 cm −1) and CO (1395 cm −1) groups. Scanning electron microscopy, high-resolution transmission electron microscopy results revealed a distribution of spherical and rod-like nanostructures with 20 nm of size. The gold nanoparticle-coated cotton fabric was evaluated for the antibacterial activity against Staphylococcus epidermidis and Escherichia coli bacterial strains which revealed remarkable inhibition at the zone of inhibition of 31 mm diameter against S. epidermidis. Further, antioxidant activity was tested for their free radical scavenging property, and the maximum antioxidant activity of the extract containing gold nanoparticles was found to be 80% at 100 µg/mL. The potent free radical scavenging property of the nanoparticles is observed at IC 50 value 16.25 µg/mL. Moreover, in vivo wound-healing activity was carried out using BALB/c mice model with infected diabetic wounds and observed the stained microscopic images at different time intervals (day 2, day 7 and day 15). It was noted that in 15 days, the wound area is completely re-epithelialized due to the presence of different morphologies such as spherical, needle and triangle nanoparticles. The reepithelialization layer is fully covered by nanoparticles on the wound area and also collagen filled in the scar tissue when compared with the control group. Conclusion: The pharmacological evaluation results of the study indicated an encouraging antibacterial and antioxidant activity of the greener synthesized gold nanoparticles tethered with aqueous extract of Acalypha indica. Moreover, we demonstrated enhanced in vivo wound-healing efficiency of the synthesized gold nano...

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MMP-9 responsive dipeptide-tempted natural protein hydrogel-based wound dressings for accelerated healing action of infected diabetic wound

Cited by 99 publications

References 73 publications

RETRACTED ARTICLE: Cerium oxide nanoparticle-loaded polyvinyl alcohol nanogels delivery for wound healing care systems on surgery

RETRACTED ARTICLE: Cerium oxide nanoparticle-loaded polyvinyl alcohol nanogels delivery for wound healing care systems on surgery

Functional silk fibroin hydrogels: preparation, properties and applications

<p>Phyto-Engineered Gold Nanoparticles (AuNPs) with Potential Antibacterial, Antioxidant, and Wound Healing Activities Under in vitro and in vivo Conditions</p>

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