MMP-9, brain edema, and length of hospital stay of patients with spontaneous supratentorial intracerebral hemorrhage after hematoma evacuation along with the administration of tigecycline

Saekhu, Mohamad; Ibrahim, Niema; Timan, Ina Susianti; Madjid, Amir S.; Muttaqin, Zainal; Ronokusumo, Teguh Asaat S.; Sastroasmoro, Sudigdo; Mahyuddin, Hilman

doi:10.13181/mji.v25i4.1520

Med J Indones

2017

DOI: 10.13181/mji.v25i4.1520

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MMP-9, brain edema, and length of hospital stay of patients with spontaneous supratentorial intracerebral hemorrhage after hematoma evacuation along with the administration of tigecycline

Mohamad Saekhu

Niema Ibrahim

Ina Susianti Timan

et al.

Abstract: ABSTRAKHasil: Didapatkan perbedaan tidak bermakna pada proporsi subjek yang mengalami penurunan kadar MMP-9 pada hari pertama (48% vs 50%; p=0,902;OR=1,(1)(2)(3)(4)(5)(6)(7) p=0,296;OR=1,9); proporsi pengurangan edema serebri (68% vs 80%; p=0,58); LOS (median 12 hari vs 13 hari p=0,256; proporsi subjek dengan LOS ≥15 hari 40% vs 27% p=0,243;OR=1,81; NNT=8).Kesimpulan: Pada pasien PISS yang dilakukan evakuasi hematoma, tigesiklin tidak menurunkan kadar MMP-9 dan derajat edema serebri, serta tidak memperpendek … Show more

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Randomized Controlled Trials on Intracerebral Hemorrhage: A Cross Sectional Retrospective Analysis of CONSORT Item Adherence

Jauch¹,

Kowark²,

Coburn³

et al. 2019

Front. Neurol.

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Object: Intracranial hemorrhage (ICH) is the second most common cause of stroke but still there is little consolidated knowledge about the optimal treatment strategies (e.g., the benefit of surgical evacuation). We evaluated the current randomized controlled trials (RCTs) on primary ICH (01.2013–03.2017) according to their fulfillment of the CONSORT statement's criteria (published in 2010) –as a marker of transparency and quality of study planning and realization.Methods: A Pubmed and a Cochrane database (including clinicaltrials.gov) search was carried out (01.2014–3.2017, respectively 01.2013–12.2013). Abstracts were screened for inclusion. Eligible full text manuscripts were assessed for the implementation of the CONSORT criteria. Citation frequencies and impact factors of the journals were related to ratio of CONSORT criteria fulfillment. Further, the risk of bias according to the Risk of bias tool 2 (RoB 2) was assessed.Results: Overall 3097 abstracts were screened for inclusion; 39 studies were suitable for final analysis. A mean fulfillment ratio of 51% (±28%) was found. A high correlation between impact factor and adherence to CONSORT criteria was shown (r = 0.7664; p < 0.0001). Citation frequency per year was related to ratio of CONSORT item fulfillment (r = 0.6747; p < 0.0001) and to the impact factor of the publishing journal (r = 0.7310; p < 0.0001). Of note, the items 10 (randomization: implementation) and 21 (generalizability) showed particularly high rates of non-fulfillment (87 and 85%). The majority of studies (95%) complied with item 2b (specific objectives or hypotheses), but strikingly objectives were mostly described vaguely. Other essential criteria such as sample size determination, definition of outcome parameters, and participant flow were only fulfilled weakly (51, 54, and 39%).Conclusions: Over 20 years after its inception there is still weak adherence to the CONSORT statement. As a consequence, conclusions are hampered by inadequate planning and/or reporting. Particularly with respect to pathologies as ICH lacking clear, evidence-based guidelines adherence to the CONSORT statement might improve research quality in order to define valuable treatment strategies.

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Randomized Controlled Trials on Intracerebral Hemorrhage: A Cross Sectional Retrospective Analysis of CONSORT Item Adherence

Jauch¹,

Kowark²,

Coburn³

et al. 2019

Front. Neurol.

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MMP-9, brain edema, and length of hospital stay of patients with spontaneous supratentorial intracerebral hemorrhage after hematoma evacuation along with the administration of tigecycline

Cited by 1 publication

References 32 publications

Randomized Controlled Trials on Intracerebral Hemorrhage: A Cross Sectional Retrospective Analysis of CONSORT Item Adherence

Randomized Controlled Trials on Intracerebral Hemorrhage: A Cross Sectional Retrospective Analysis of CONSORT Item Adherence

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