MMP-8-Responsive Polyethylene Glycol Hydrogel for Intraoral Drug Delivery

Guo, Jingyi; Sun, Hanxiao; Wang, Lei; Tang, Yufeng; Hong, Sihui; Yang, Hongye; Tay, Franklin R.; Huang, Cui

doi:10.1177/0022034519831931

Cited by 47 publications

(36 citation statements)

References 29 publications

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“…An MMP 8-responsive, polymeric hydrogel was developed from a diacrylate-containing polyethylene glycol-based moiety, along with a cysteine-terminated peptide cross-linker (CGPQG↓IWGQC). The hydrogels were encapsulated with BSA, minocycline hydrochloride, and antibacterial peptide KSL to target chronic periodontitis and peri-implantitis [ 158 ].…”

Section: Stimuli-responsive Polymeric Nanocarriers For Drug and Gmentioning

confidence: 99%

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

et al. 2020

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In the past few decades, polymeric nanocarriers have been recognized as promising tools and have gained attention from researchers for their potential to efficiently deliver bioactive compounds, including drugs, proteins, genes, nucleic acids, etc., in pharmaceutical and biomedical applications. Remarkably, these polymeric nanocarriers could be further modified as stimuli-responsive systems based on the mechanism of triggered release, i.e., response to a specific stimulus, either endogenous (pH, enzymes, temperature, redox values, hypoxia, glucose levels) or exogenous (light, magnetism, ultrasound, electrical pulses) for the effective biodistribution and controlled release of drugs or genes at specific sites. Various nanoparticles (NPs) have been functionalized and used as templates for imaging systems in the form of metallic NPs, dendrimers, polymeric NPs, quantum dots, and liposomes. The use of polymeric nanocarriers for imaging and to deliver active compounds has attracted considerable interest in various cancer therapy fields. So-called smart nanopolymer systems are built to respond to certain stimuli such as temperature, pH, light intensity and wavelength, and electrical, magnetic and ultrasonic fields. Many imaging techniques have been explored including optical imaging, magnetic resonance imaging (MRI), nuclear imaging, ultrasound, photoacoustic imaging (PAI), single photon emission computed tomography (SPECT), and positron emission tomography (PET). This review reports on the most recent developments in imaging methods by analyzing examples of smart nanopolymers that can be imaged using one or more imaging techniques. Unique features, including nontoxicity, water solubility, biocompatibility, and the presence of multiple functional groups, designate polymeric nanocues as attractive nanomedicine candidates. In this context, we summarize various classes of multifunctional, polymeric, nano-sized formulations such as liposomes, micelles, nanogels, and dendrimers.

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Section: Stimuli-responsive Polymeric Nanocarriers For Drug and Gmentioning

confidence: 99%

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

et al. 2020

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“…Therefore, MMPs could act as stimuli for novel DDS. Guo et al designed an MMP-8-responsive hydrogel and demonstrated that it was a promising candidate for on-demand intraoral localized drug delivery [48].…”

Section: The Stimuli-responsive Dds For Oral Infectious Diseasesmentioning

confidence: 99%

“…The DDS could react to specific conditions of oral cavity such as pH, temperature, enzymes, and provide more accurate drug delivery. These intelligent materials provide more possibilities for oral biomaterials research and the treatment for oral diseases [47][48][49].In this review, we will focus on the recent work and emerging applications of DDS in the prevention and treatment of common oral infectious diseases, including dental caries, periodontitis, peri-implantitis, and oral candidiasis, in order to find out the current challenges and opportunities for future research.…”

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Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

et al. 2020

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The oral cavity is a unique complex ecosystem colonized with huge numbers of microorganism species. Oral cavities are closely associated with oral health and sequentially with systemic health. Many factors might cause the shift of composition of oral microbiota, thus leading to the dysbiosis of oral micro-environment and oral infectious diseases. Local therapies and dental hygiene procedures are the main kinds of treatment. Currently, oral drug delivery systems (DDS) have drawn great attention, and are considered as important adjuvant therapy for oral infectious diseases. DDS are devices that could transport and release the therapeutic drugs or bioactive agents to a certain site and a certain rate in vivo. They could significantly increase the therapeutic effect and reduce the side effect compared with traditional medicine. In the review, emerging recent applications of DDS in the treatment for oral infectious diseases have been summarized, including dental caries, periodontitis, peri-implantitis and oral candidiasis. Furthermore, oral stimuli-responsive DDS, also known as "smart" DDS, have been reported recently, which could react to oral environment and provide more accurate drug delivery or release. In this article, oral smart DDS have also been reviewed. The limits have been discussed, and the research potential demonstrates good prospects.Molecules 2020, 25, 516 2 of 29 problems. For example, systemic antibiotics such as tetracycline, beta-lactam antibiotics, nitroimidazoles have been used, especially in cases of periodontal diseases and peri-implantitis [12]. However, systemic antibiotics could cause problems like drug resistance, dysbacteriosis, and systemic side effects [13,14]. The antibacterial effect is also limited as very little could arrive at the oral lesion area after systemic circulation [15][16][17]. Fluoride in drinking water has been used for the prevention of dental caries but might cause excessive intake, leading to fluorosis [18]. Therefore, local drug therapy is now more considered for oral infectious diseases [19,20]. However, the conventional forms of local therapy, like drug suspension or rinse of anti-infection agents, could be easily washed off and thus could not last long in the oral cavity. Complex local lesions like deep periodontal pockets and teeth fissure are also difficult to reach. In order to improve the effect of prophylaxis and treatment, more precise targeting therapy is quite essential [21,22]. Therefore, drug delivery systems have drawn great attention in recent decades in oral infectious diseases. Drug delivery systems (DDS) are devices that can transport and release the therapeutic agents or bioactive substances to certain sites at certain rates in vivo [23,24], usually composed of the carriers and associated therapeutics [25]. They have been widely explored in biomedical research. With local drug administration and controlled drug release, DDS could provide higher curative efficiency and fewer side effects [23,26,27]. With all these advantages, DDS has been reported w...

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“…Among drugs profile, doxycycline, tetracycline, metronidazole, and minocycline have been selected as antibiotics to be incorporated in the delivery system . Besides antibiotics, antimicrobial peptides have been investigated as drug possibilities to fight oral infections . Further, depending on the target, biomaterial modifications can be employed on different parts of implants to either prevent infection or treat peri‐implantitis.…”

Section: Biomaterial‐based Solutions As Future Perspectives To Prevenmentioning

confidence: 99%

Biomaterial‐based possibilities for managing peri‐implantitis

Ávila

Oirschot

Beucken

2019

J of Periodontal Research

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Peri‐implantitis is an inflammatory disease of hard and soft tissues around osseointegrated implants, followed by a progressive damage of alveolar bone. Oral microorganisms can adhere to all types of surfaces by the production of multiple adhesive factors. Inherent properties of materials will influence not only the number of microorganisms, but also their profile and adhesion force onto the material surface. In this perspective, strategies to reduce the adhesion of pathogenic microorganisms on dental implants and their components should be investigated in modern rehabilitation concepts in implant dentistry. To date, several metallic nanoparticle films have been developed to reduce the growth of pathogenic bacteria. However, the main drawback in these approaches is the potential toxicity and accumulative effect of the metals over time. In view of biological issues and in attempt to prevent and/or treat peri‐implantitis, biomaterials as carriers of antimicrobial substances have attracted special attention for application as coatings on dental implant devices. This review will focus on biomaterial‐based possibilities to prevent and/or treat peri‐implantitis by describing concepts and dental implant components suitable for engagement in preventing and treating this disease. Additionally, we raise important criteria referring to the geometric parameters of dental implants and their components, which can directly affect peri‐implant tissue conditions. Finally, we overview currently available biomaterial systems that can be used in the field of oral implantology.

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MMP-8-Responsive Polyethylene Glycol Hydrogel for Intraoral Drug Delivery

Cited by 47 publications

References 29 publications

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

Biomaterial‐based possibilities for managing peri‐implantitis

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