MMP-7, MMP-8, and MMP-9 in oral and cutaneous squamous cell carcinomas

Ahmed, Abdirisak; Haglund, Caj; Virolainen, Susanna; Häyry, Valtteri; Atula, Timo; Kontio, Risto; Salo, Tuula; Sorsa, Timo; Hagström, Jaana

doi:10.1016/j.oooo.2014.12.019

Cited by 28 publications

(24 citation statements)

References 52 publications

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“…A study by Ahmad et al on MMP-7, -8 and -9 in oral and cutaneous squamous cell cancers showed MMP-7 expression to be elevated at the invasion front and MMP-9 mildly expressed. However, contrary to our results MMP-8 was not found in the OSCC but was present, along with MMP 9, in peri-cancerous inflammatory cells 17. A study by Korpi et al stated a positive association of MMP-8 with patient survival thus hypothesizing a protective role of MMP-8 18.…”

Section: Discussioncontrasting

confidence: 99%

Estimation of serum matrix metalloproteinases among patients of oral squamous cell carcinoma

et al. 2019

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Objective: To estimate the serum levels of matrix metalloproteinases in oral squamous cell carcinoma patients and in healthy subjects. Methods: In this observational study, biopsy diagnosed oral squamous cell carcinoma patients (n= 38) were recruited from Mayo Hospital, Lahore during 2016 to 2017. Age and gender matched Controls (n= 38) were also included. Venous blood sample of each participant was drawn, serum separated and the levels of matrix metalloproteinases were measured by multiplex ELISA. Results: Serum levels of MMP-1, -8, -10, -12 and -13 in OSCC patients showed statistically significant increase as compared to control group (p < 0.01). The MMP-12 predicted the presence of OSCC with highest AUC of 0.836 (95% CI [0.733 to 0.911]) for sensitivity and specificity of 80% and 78.9%, respectively for a cut-off value of 16.13 pg/ml. Conclusions: MMP-12 has been found to have significant sensitivity and specificity to qualify as a diagnostic biomarker. How to cite this:Choudhry N, Sarmad S, Waheed NA, Gondal AJ. Estimation of serum matrix metalloproteinases among patients of oral squamous cell carcinoma. Pak J Med Sci. 2019;35(1):252-256. doi: https://doi.org/doi.org/10.12669/pjms.35.1.68 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussioncontrasting

confidence: 99%

Estimation of serum matrix metalloproteinases among patients of oral squamous cell carcinoma

et al. 2019

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“…Fibroblast-derived MMP-2 is expressed to a greater degree during the earlier stages of squamous carcinogenesis, resulting in the initiation of tumor growth. Inflammatory cell-derived MMP-9 promotes tumor invasion and angiogenesis by mediating the release of TGF-β and VEGF [ 64 , 66 , 67 ]. The expression of VEGF is also governed by hypoxia-inducible factor-1α (HIF-1α).…”

Section: Photocarcinogenesismentioning

confidence: 99%

Role of Matrix Metalloproteinases in Photoaging and Photocarcinogenesis

Pittayapruek

Meephansan

Prapapan

et al. 2016

IJMS

783

666

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Matrix metalloproteinases (MMPs) are zinc-containing endopeptidases with an extensive range of substrate specificities. Collectively, these enzymes are able to degrade various components of extracellular matrix (ECM) proteins. Based on their structure and substrate specificity, they can be categorized into five main subgroups, namely (1) collagenases (MMP-1, MMP-8 and MMP-13); (2) gelatinases (MMP-2 and MMP-9); (3) stromelysins (MMP-3, MMP-10 and MMP-11); (4) matrilysins (MMP-7 and MMP-26); and (5) membrane-type (MT) MMPs (MMP-14, MMP-15, and MMP-16). The alterations made to the ECM by MMPs might contribute in skin wrinkling, a characteristic of premature skin aging. In photocarcinogenesis, degradation of ECM is the initial step towards tumor cell invasion, to invade both the basement membrane and the surrounding stroma that mainly comprises fibrillar collagens. Additionally, MMPs are involved in angiogenesis, which promotes cancer cell growth and migration. In this review, we focus on the present knowledge about premature skin aging and skin cancers such as basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma, with our main focus on members of the MMP family and their functions.

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“…Additionally, MMPs and TIMPs affect apoptosis, cancer cell growth, and immune surveillance, which in turn can promote invasion and metastasis [9, 15, 16]. Increased expression of certain MMPs can be detected in most human cancers, and their overexpression is associated with poor prognosis [9, 17, 18]. On the other hand, regardless of the active role of various MMPs in tumor progression, matrix metalloproteinase-8 (MMP-8) may have antitumor activity [19–21].…”

Section: Introductionmentioning

confidence: 99%

High levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) in the serum are associated with poor prognosis in HPV-negative squamous cell oropharyngeal cancer

Carpén

Sorsa

Jouhi

et al. 2019

Cancer Immunol Immunother

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Background An emerging subset of oropharyngeal squamous cell carcinomas (OPSCC) is caused by HPV. HPV-positive OPSCC has a better prognosis than HPV-negative OPSCC, but other prognostic markers for these two different diseases are scarce. Our aim was to evaluate serum levels and tumor expression of matrix metalloproteinase-8 (MMP-8) and tissue inhibitor of metalloproteinase-1 (TIMP-1) and to assess their prognostic role in HPV-positive and HPV-negative OPSCC. Materials and methods A total of 90 consecutive OPSCC patients diagnosed and treated with curative intent at the Helsinki University Hospital between 2012 and 2016 were included. Serum samples were prospectively collected. An immunofluorometric assay and an enzyme-linked immunosorbent assay were used to determine MMP-8 and TIMP-1 serum concentrations, respectively. HPV status of the tumors was determined using a combination of HPV-DNA genotyping and p16-INK4a immunohistochemistry. The endpoints were overall survival (OS) and disease-free survival (DFS). Results High TIMP-1 serum levels were strongly and independently associated with poorer OS (adjusted HR 14.7, 95% CI 1.8–117.4, p = 0.011) and DFS (adjusted HR 8.7, 95% CI 1.3–57.1, p = 0.024) among HPV-negative patients; this association was not observed in HPV-positive OPSCC. Although TIMP-1 was immunoexpressed in the majority of the tumor tissue samples, the level of immunoexpression was not associated with prognosis, nor did MMP-8 serum levels. Conclusion Our results indicate that serum TIMP-1 levels may serve as an independent prognostic marker for HPV-negative OPSCC patients.

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MMP-7, MMP-8, and MMP-9 in oral and cutaneous squamous cell carcinomas

Cited by 28 publications

References 52 publications

Estimation of serum matrix metalloproteinases among patients of oral squamous cell carcinoma

Estimation of serum matrix metalloproteinases among patients of oral squamous cell carcinoma

Role of Matrix Metalloproteinases in Photoaging and Photocarcinogenesis

High levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) in the serum are associated with poor prognosis in HPV-negative squamous cell oropharyngeal cancer

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