MMP-2 is localized to the mitochondria-associated membrane of the heart

Hughes, Bryan; Fan, Xiaohu; Cho, Woo Jung; Schulz, Richard

doi:10.1152/ajpheart.00909.2013

Cited by 43 publications

(27 citation statements)

References 48 publications

(61 reference statements)

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“…24 Overexpression and activity of MMP-2 and MMP-9 could accelerate the development and rupture of atherosclerotic plaques. 25 In addition to their canonical function in ECM remodeling, researches in the last decade have highlighted new MMP-2 functions, including proteolysis of novel substrates beyond ECM proteins such as troponin I, 26 localization to subcellular organelles such as mitochondria, 27 and proteolysis of susceptible intracellular proteins in those subcellular compartments such as monocyte chemoattractant protein-3. 28 Therefore, inhibition of MMP-2 and MMP-9 is considered as an important target for therapeutic intervention of cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

Polyphenols and Polypeptides in Chinese Rice Wine Inhibit Homocysteine-induced Proliferation and Migration of Vascular Smooth Muscle Cells

Meng

Liu

Zhou

et al. 2016

Journal of Cardiovascular Pharmacology

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The beneficial effect of Chinese rice wine on atherosclerosis has been proved, but the exact components that have the cardiovascular protective effect are still unknown. This study aimed to explore the exact ingredients in Chinese rice wine that could inhibit homocysteine (Hcy)-induced vascular smooth muscle cell (VSMC) proliferation and migration. VSMCs were divided into 7 groups: control, Hcy (1 mmol/L), Hcy + oligosaccharide, Hcy + polypeptides, Hcy + polyphenols, Hcy + alcohol, and Hcy + Chinese rice wine. methyl thiazolyl tetrazolium (MTT) assay, Transwell chambers, and wound-healing assay were used to test the proliferation and migratory ability of the VSMCs. Western blot and gelatin zymography were used to investigate the expressions and activities of metal matrix proteinase 2/9 (MMP-2/9) and tissue inhibitor of metalloproteinase 2 (TIMP-2) in VSMCs. Polypeptides and polyphenols in the Chinese rice wine reduced the proliferation and migration ability of the VSMCs. Furthermore, they also decreased the expression and activity of MMP-2/9 but had no obvious impact on the expression of TIMP-2 in each group. This study further confirms that polypeptides and polyphenols in the Chinese rice wine could inhibit Hcy-induced proliferation and migration of VSMCs and maintain the balance between matrix metalloproteinases (MMPs) and TIMPs.

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Section: Discussionmentioning

confidence: 99%

Polyphenols and Polypeptides in Chinese Rice Wine Inhibit Homocysteine-induced Proliferation and Migration of Vascular Smooth Muscle Cells

Meng

Liu

Zhou

et al. 2016

Journal of Cardiovascular Pharmacology

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“…We and others have shown that MMP-2, -7, -8, -9, -12, and -14 increase post-MI. [12, 21-33] In particular, MMP-9 and MMP-12 have been shown to increase at both the gene and protein level, and both pro- and active protein forms are elevated post-MI. [12, 34] Both increase in the infarct at day 1 post-MI and remain elevated through days 5-7 post-MI.…”

Section: Carma Postulate 1: the Mmp Increases Post-mimentioning

confidence: 99%

Matrix metalloproteinases as input and output signals for post-myocardial infarction remodeling

Lindsey

Iyer

Jung

et al. 2016

Journal of Molecular and Cellular Cardiology

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Despite current optimal therapeutic regimens, approximately one in four patients diagnosed with myocardial infarction (MI) will go on to develop congestive heart failure, and heart failure has a high five-year mortality rate of 50%. Elucidating mechanisms whereby heart failure develops post-MI, therefore, is highly needed. Matrix metalloproteinases (MMPs) are key enzymes involved in post-MI remodeling of the left ventricle (LV). While MMPs process cytokine and extracellular matrix (ECM) substrates to regulate the inflammatory and fibrotic components of the wound healing response to MI, MMPs also serve as upstream signaling initiators with direct actions on cell signaling cascades. In this review, we summarize the current literature regarding MMP roles in post-MI LV remodeling. We also identify the current knowledge gaps and provide templates for experiments to fill these gaps. A more complete understanding of MMP roles, particularly with regards to upstream signaling roles, may provide new strategies to limit adverse LV remodeling.

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“…Further, the ability of this isoform to cleave calreticulin, an important regulator of ER-MAM Ca 2+ homeostasis, has been demonstrated. [38]…”

Section: Mmp-2 Localized In or Near Mitochondriamentioning

confidence: 99%

Myocardial matrix metalloproteinase-2: inside out and upside down

DeCoux

Lindsey

Villarreal

et al. 2014

Journal of Molecular and Cellular Cardiology

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Since their inaugural discovery in the early 1960s, matrix metalloproteinases (MMPs) have been shown to mediate multiple physiological and pathological processes. In addition to their canonical function in extracellular matrix (ECM) remodeling, research in the last decade has highlighted new MMP functions, including proteolysis of novel substrates beyond ECM proteins, MMP localization to subcellular organelles, and proteolysis of susceptible intracellular proteins in those subcellular compartments. This review will provide a comparison of the extracellular and intracellular roles of MMPs, illustrating that MMPs are far more interesting than the one-dimensional view originally taken. We focus on the roles of MMP-2 in cardiac injury and repair, as this is one of the most studied MMPs in the cardiovascular field. We will highlight how understanding all dimensions, such as localization of activity and timing of interventions, will increase the translational potential of research findings. Building upon old ideas and turning them inside out and upside down will help us to better understand how to move the MMP field forward.

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MMP-2 is localized to the mitochondria-associated membrane of the heart

Cited by 43 publications

References 48 publications

Polyphenols and Polypeptides in Chinese Rice Wine Inhibit Homocysteine-induced Proliferation and Migration of Vascular Smooth Muscle Cells

Polyphenols and Polypeptides in Chinese Rice Wine Inhibit Homocysteine-induced Proliferation and Migration of Vascular Smooth Muscle Cells

Matrix metalloproteinases as input and output signals for post-myocardial infarction remodeling

Myocardial matrix metalloproteinase-2: inside out and upside down

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