MMP−2 Expression in Skeletal Muscle after Strength Training

Deus, Ana P. L.; Bassi, Daniela; Rp, Simões; Oliveira, Cláudio Ricardo de; Baldissera, Vilmar; Marqueti, Rita de Cássia; Araújo, Heloísa Sobreiro Selistre de; Arena, Ross; Borghi‐Silva, Audrey

doi:10.1055/s-0031-1291224

Cited by 25 publications

(37 citation statements)

References 15 publications

(27 reference statements)

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“…Previous studies have shown that the matrix metallopeptidases (MMPs) are important for skeletal muscle remodeling (50) and are increased after intense exercise training (12). Our study showed that at least two of the MMPs are significantly decreased with age (MMP2, P ϭ 8.9E-11; MMP14, P ϭ 6.4E-07; Supplemental Table S2).…”

Section: Exercise Effects (Exhausted Vs Rest)supporting

confidence: 52%

Selection-, age-, and exercise-dependence of skeletal muscle gene expression patterns in a rat model of metabolic fitness

Ren

Koch

Britton

et al. 2016

Physiological Genomics

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Intrinsic aerobic exercise capacity can influence many complex traits including obesity and aging. To study this connection we established two rat lines by divergent selection of untrained aerobic capacity. After 32 generations the high capacity runners (HCR) and low capacity runners (LCR) differed in endurance running distance and body fat, blood glucose, other health indicators, and natural life span. To understand the interplay among genetic differences, chronological age, and acute exercise we performed microarray-based gene expression analyses in skeletal muscle with a 2×2×2 design to simultaneously compare HCR and LCR, old and young animals, and rest and exhaustion. Transcripts for mitochondrial function are expressed higher in HCRs than LCRs at both rest and exhaustion and for both age groups. Expression of cell adhesion and extracellular matrix genes tend to decrease with age. This and other age effects are more prominent in LCRs than HCRs, suggesting that HCRs have a slower aging process and this may be partly due to their better metabolic health. Strenuous exercise mainly affects transcription regulation and cellular response. The effects of any one factor often depend on the other two. For example, there are ∼140 and ∼110 line-exercise "interacting" genes for old and young animals, respectively. Many genes highlighted in our study are consistent with prior reports, but many others are novel. The gene- and pathway-level statistics for the main effects, either overall or stratified, and for all possible interactions, represent a rich reference dataset for understanding the interdependence among lines, aging, and exercise.

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Section: Exercise Effects (Exhausted Vs Rest)supporting

confidence: 52%

Selection-, age-, and exercise-dependence of skeletal muscle gene expression patterns in a rat model of metabolic fitness

Ren

Koch

Britton

et al. 2016

Physiological Genomics

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“…Macedo et al 16 showed significant muscular strength increases using only 60% of the rodent maximum voluntary carrying load capacity. Recently, Deus et al 17 tested two protocols: low (animal body weight) versus moderate-high (75% B.W to muscle fatigue) training loads. As expected, the author has demonstrated greater carrying capacity through heavier training load.…”

Section: Discussionmentioning

confidence: 99%

Morphological Adjustments of the Radial Nerve Are Intensity-Dependent

Carbone

Neto

Gama

et al. 2017

Rev Bras Med Esporte

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Introduction: Peripheral nerve adaptation is critical for strength gains. However, information about intensity effects on nerve morphology is scarce. Objective: To compare the effects of different intensities of resistance training on radial nerve structures. Methods: Rats were divided into three groups: control (GC), training with 50% (GF1) and training 75% (GF2) of the animal's body weight. The morphological analysis of the nerve was done by light and transmission electron microscopy. One-way ANOVA and the Tukey's post hoc test were applied and the significance level was set at p≤0.05. Results: Training groups had an increase of strength compared to GC (p≤0.05). All measured nerve components (mean area and diameter of myelin fibers and axons, mean area and thickness of the myelin sheath, and of neurofilaments and microtubules) were higher in GF2 compared to the other (p≤0.05). Conclusion: Results demonstrated greater morphological changes on radial nerve after heavier loads. This can be important for rehabilitation therapies, training, and progression.

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“…It appears that exercise itself has independent effects on skeletal muscle ECM during healthy conditions. Four of the six studies on this area were focused on the effect of exercise on MMP in healthy individuals and reported similar increases in gene expression, protein content and/or activity of gelatinases and MMP-14 (14,52,58,59). Those findings combined with increases in the gene expression of TIMPs (14) and PGs (52) might indicate a turnover of ECM structure after exercise training potentially leading to an attenuation of ECM accumulation as seen during chronic metabolic disease in humans (6,9).…”

Section: Effects Of Exercise Training On Skeletal Muscle Extracellulamentioning

confidence: 96%

The emerging role of skeletal muscle extracellular matrix remodelling in obesity and exercise

et al. 2017

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Skeletal muscle extracellular matrix remodelling has been proposed as a new feature associated with obesity and metabolic dysfunction. Exercise training improves muscle function in obesity, which may be mediated by regulatory effects on the muscle extracellular matrix. This review examined available literature on skeletal muscle extracellular matrix remodelling during obesity and the effects of exercise. A non-systematic literature review was performed on PubMed of publications from 1970 to 2015. A total of 37 studies from humans and animals were retained. Studies reported overall increases in gene and protein expression of different types of collagen, growth factors and enzymatic regulators of the skeletal muscle extracellular matrix in obesity. Only two studies investigated the effects of exercise on skeletal muscle extracellular matrix during obesity, with both suggesting a regulatory effect of exercise. The effects of exercise on muscle extracellular matrix seem to be influenced by the duration and type of exercise training with variable effects from a single session compared with a longer duration of exercise. More studies are needed to elucidate the mechanisms behind skeletal muscle extracellular matrix remodelling during obesity and the effects of exercise.

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MMP−2 Expression in Skeletal Muscle after Strength Training

Cited by 25 publications

References 15 publications

Selection-, age-, and exercise-dependence of skeletal muscle gene expression patterns in a rat model of metabolic fitness

Selection-, age-, and exercise-dependence of skeletal muscle gene expression patterns in a rat model of metabolic fitness

Morphological Adjustments of the Radial Nerve Are Intensity-Dependent

The emerging role of skeletal muscle extracellular matrix remodelling in obesity and exercise

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