MMP-2 and MMP-9 contribute to the angiogenic effect produced by hypoxia/15-HETE in pulmonary endothelial cells

Liu, Ying; Zhang, Hongyue; Yan, Lei; Du, Wei; Zhang, Min; Chen, He; Zhang, Lixin; Guang-qun, LI; Li, Jijin; Dong, Yuxuan; Zhu, Daling

doi:10.1016/j.yjmcc.2018.06.006

Cited by 74 publications

(56 citation statements)

References 44 publications

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“…In hypoxia, the direct target of injury are endothelial cells. Hypoxia induces cell proliferation in the vascular wall and results in increased MMP-9 expression in VSMCs [104]. These cells enhance MMPs activity in hypoxic areas.…”

Section: Mmps In Plaque Neovascularizationmentioning

confidence: 99%

Matrix Metalloproteinases as Biomarkers of Atherosclerotic Plaque Instability

Olejarz

Łacheta

Kubiak-Tomaszewska

2020

IJMS

129

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Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases responsible for tissue remodeling and degradation of extracellular matrix (ECM) proteins. MMPs may modulate various cellular and signaling pathways in atherosclerosis responsible for progression and rupture of atherosclerotic plaques. The effect of MMPs polymorphisms and the expression of MMPs in both the atherosclerotic plaque and plasma was shown. They are independent predictors of atherosclerotic plaque instability in stable coronary heart disease (CHD) patients. Increased levels of MMPs in patients with advanced cardiovascular disease (CAD) and acute coronary syndrome (ACS) was associated with future risk of cardiovascular events. These data confirm that MMPs may be biomarkers in plaque instability as they target in potential drug therapies for atherosclerosis. They provide important prognostic information, independent of traditional risk factors, and may turn out to be useful in improving risk stratification.

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Section: Mmps In Plaque Neovascularizationmentioning

confidence: 99%

Matrix Metalloproteinases as Biomarkers of Atherosclerotic Plaque Instability

Olejarz

Łacheta

Kubiak-Tomaszewska

2020

IJMS

129

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“…These sequential events are orchestrated by a variety of growth factors, ECM-degrading enzymes and adhesion receptors [ 73 , 74 ]. Among these molecules, MMP-9 plays a prominent role in angiogenesis by cooperating with VEGF and the αvβ3 integrin ( Table 1 ) [ 11 , 73 , 74 , 134 , 135 , 136 ]. Specifically, the MMP-9 produced by metastatic tumor cells and metastasis-infiltrating neutrophils and/or macrophages breaks down the vessel basement membrane and perivascular matrix, thereby generating ECM fragments [ 11 , 20 , 26 , 27 , 28 , 29 , 92 , 134 ].…”

Section: Mmp-9 Favors Tumor Cell Adaptation To the Microenvironmenmentioning

confidence: 99%

The Impact of Matrix Metalloproteinase-9 on the Sequential Steps of the Metastatic Process

Barillari

2020

IJMS

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In industrialized countries, cancer is the second leading cause of death after cardiovascular disease. Most cancer patients die because of metastases, which consist of the self-transplantation of malignant cells in anatomical sites other than the one from where the tumor arose. Disseminated cancer cells retain the phenotypic features of the primary tumor, and display very poor differentiation indices and functional regulation. Upon arrival at the target organ, they replace preexisting, normal cells, thereby permanently compromising the patient’s health; the metastasis can, in turn, metastasize. The spread of cancer cells implies the degradation of the extracellular matrix by a variety of enzymes, among which the matrix metalloproteinase (MMP)-9 is particularly effective. This article reviews the available published literature concerning the important role that MMP-9 has in the metastatic process. Additionally, information is provided on therapeutic approaches aimed at counteracting, or even preventing, the development of metastasis via the use of MMP-9 antagonists.

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“…4HR increases M2 markers, and broadspectrum matrix metalloproteinase (MMP) inhibitor (PD166793) can reduce 4HR-induced VEGF expression. However, MMPs are also highly expressed in the inflammatory phase, and the expression of MMPs is mostly regulated by hypoxic stress [11]. Interestingly, the action of PD166793 is mediated by chelating zinc ion [12].…”

Section: Introductionmentioning

confidence: 99%

4-Hexylresorcinol induced angiogenesis potential in human endothelial cells

Kim

Lee

2020

Maxillofac Plast Reconstr Surg

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Background: 4-Hexylresorcinol (4HR) is able to increase angiogenesis. However, its molecular mechanism in the human endothelial cells has not been clarified. Methods: As endothelial cells are important in angiogenesis, we treated the human umbilical vein endothelial cells (HUVECs) with 4HR and investigated protein expressional changes by immunoprecipitation high-performance liquid chromatography (IP-HPLC) using 96 antisera. Results: Here, we found that 4HR upregulated transforming growth factor-β (TGF-β)/SMAD/vascular endothelial growth factor (VEGF) signaling, RAF-B/ERK and p38 signaling, and M2 macrophage polarization pathways. 4HR also increased expression of caspases and subsequent cellular apoptosis. Mechanistically, 4HR increased TGF-β1 production and subsequent activation of SMADs/VEGFs, RAF-B/ERK and p38 signaling, and M2 macrophage polarization. Conclusion: Collectively, 4HR activates TGF-β/SMAD/VEGF signaling in endothelial cells and induced vascular regeneration and remodeling for wound healing.

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MMP-2 and MMP-9 contribute to the angiogenic effect produced by hypoxia/15-HETE in pulmonary endothelial cells

Cited by 74 publications

References 44 publications

Matrix Metalloproteinases as Biomarkers of Atherosclerotic Plaque Instability

Matrix Metalloproteinases as Biomarkers of Atherosclerotic Plaque Instability

The Impact of Matrix Metalloproteinase-9 on the Sequential Steps of the Metastatic Process

4-Hexylresorcinol induced angiogenesis potential in human endothelial cells

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