MMP‐14 mediated MMP‐9 expression is involved in TGF‐beta1‐induced keratinocyte migration

Seomun, Young; Kim, Jong-Tak; Joo, Choun‐Ki

doi:10.1002/jcb.21675

Cited by 53 publications

(45 citation statements)

References 31 publications

(57 reference statements)

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“…In line with these results, PDGF was found to be a powerful chemotactic factor for MSCs, including osteoblasts from human and rat tissues (Fiedler et al, 2002). In addition, TGF-β is known to be an important component of the overall process of wound healing, triggering a multitude of reactions needed for cell migration (Seomun et al, 2008).…”

Section: Discussionmentioning

confidence: 60%

In vitromigration capacity of human adipose tissue-derived mesenchymal stem cells reflects their expression of receptors for chemokines and growth factors

2011

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Section: Discussionmentioning

confidence: 60%

In vitromigration capacity of human adipose tissue-derived mesenchymal stem cells reflects their expression of receptors for chemokines and growth factors

2011

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“…JNK activity has been known upregulated in migrating epidermis during wound re-epithelialization (Deng et al, 2006); the factors controlling JNK activity, however, are largely unclear. In this regard, cytokines, such as TNF-a and transforming growth factor-b, and integrins and their ligands, such as integrin a6b4 and lamin-5, are implicated to be the candidates, as they activate JNK in keratinocytes in vitro (Nguyen et al, 2000;Kadrmas et al, 2004;Seomun et al, 2008;Bahar-Shany et al, 2010). In contrast to previous findings, our in vivo study showed that JNK activity was www.jidonline.org 233 significantly altered by CD9 deficiency, suggesting a previously unreported, CD9-mediated mechanism for the regulation of JNK in migrating epidermis during wound healing.…”

Section: Discussionmentioning

confidence: 99%

CD9 Is Critical for Cutaneous Wound Healing through JNK Signaling

Zhang

Dong

et al. 2012

Journal of Investigative Dermatology

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Cutaneous injury triggers a cascade of signaling events essential for wound re-epithelialization. CD9, a cell-surface protein, has been implicated in a number of cellular processes by coupling to intracellular signaling; however, its exact role in wound healing remains unidentified. We reported that CD9 was downregulated in migrating epidermis, and reelevated to basal level when re-epithelialization was completed. Although low level of CD9 appears to be required for normal wound healing, a significant healing delay was found in CD9-null mice, with wounds gaping wider on day 5 and day 7 post wounding. Further analysis showed that re-epithelialization was adversely affected in CD9-null mice, due to impaired migration of epidermis. Notably, CD9 deficiency caused a persistent enhancement of C-JUN NH2 terminal kinase (JNK) signaling primarily in migrating epidermis with abnormal elevation of matrix metalloproteinase (MMP)-9 detected in CD9-null wounds, leading to excessive degradation of type IV collagen, and thus a defective basement membrane at the wound site. JNK suppression reduced MMP-9 production and therefore ameliorated the healing delay with the appearance of significantly elongated migrating epidermis in CD9-null mice. Our study demonstrated the importance of CD9 in wound re-epithelialization, linking this molecule directly to basement membrane formation and epidermal migration through participating in the regulation of the JNK/MMP-9 pathway.

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“…VEGF supports wound healing by stimulation of vascular permeability and leukocyte recruitment, survival, proliferation, migration, and invasion of endothelial cells, as well as modulation of bone remodeling [55–57]. TGF β , another growth factor, stimulates wound healing by its activating effects on migration, chemotaxis, and proliferation of monocytes/macrophages, fibroblasts, and endothelial cells, keratinocyte migration and reepithelialization, extracellular matrix production, and stem cell differentiation [58–60]. POSTN supports formation of high stiffness collagen through effective collagen cross-linking.…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effects of Adiponectin on Periodontal Ligament Cells under Normal and Regenerative Conditions

Nokhbehsaim

Keser

Nogueira

et al. 2014

Journal of Diabetes Research

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Type 2 diabetes and obesity are increasing worldwide and linked to periodontitis, a chronic disease which is characterized by the irreversible destruction of the tooth-supporting tissues, that is, periodontium. The mechanisms underlying the association of diabetes mellitus and obesity with periodontal destruction and compromised periodontal healing are not well understood, but decreased plasma levels of adiponectin, as found in diabetic and obese individuals, might be a critical mechanistic link. The aim of this in vitro study was to examine the effects of adiponectin on periodontal ligament (PDL) cells under normal and regenerative conditions, and to study the regulation of adiponectin and its receptors in these cells. Adiponectin stimulated significantly the expression of growth factors and extracellular matrix, proliferation, and in vitro wound healing, reduced significantly the constitutive tumor necrosis factor-α expression, and caused a significant upregulation of its own expression. The beneficial actions of enamel matrix derivative on a number of PDL cell functions critical for periodontal regeneration were partially enhanced by adiponectin. The periodontopathogen Porphyromonas gingivalis inhibited the adiponectin expression and stimulated the expression of its receptors. In conclusion, reduced levels of adiponectin, as found in type 2 diabetes and obesity, may compromise periodontal health and healing.

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MMP‐14 mediated MMP‐9 expression is involved in TGF‐beta1‐induced keratinocyte migration

Cited by 53 publications

References 31 publications

In vitromigration capacity of human adipose tissue-derived mesenchymal stem cells reflects their expression of receptors for chemokines and growth factors

In vitromigration capacity of human adipose tissue-derived mesenchymal stem cells reflects their expression of receptors for chemokines and growth factors

CD9 Is Critical for Cutaneous Wound Healing through JNK Signaling

Beneficial Effects of Adiponectin on Periodontal Ligament Cells under Normal and Regenerative Conditions

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