“…To extend these studies, the current work has utilized zebrafish as an experimental model and has focused on the expression of a subset of MMPs (MT1-MMP and MMP-2) and a modulator of MMP activity (TIMP-2) during fin regeneration. These three molecules were selected because they can act 1) independently of one another (Nagase and Woessner, 1999) or 2) together as a unit during development (Strongin et al, 1995;Butler et al, 1998;D'Angelo et al, 2000). When functioning as a unit, they are involved in the activation of pro-MMP-2 to its active form (Strongin et al, 1995;Butler et al, 1998).…”