MMP-1 polymorphism and its relationship to pathological processes

Arakaki, Pricila A.; Marques, Marcelo Rocha; Santos, Maria Cristina Leme Godoy dos

doi:10.1007/s12038-009-0035-1

Cited by 64 publications

(53 citation statements)

References 56 publications

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“…The MMP1 1G/2G polymorphism (rs1799750) has previously been associated with gene expression [20], but this is the first description of an effect on transcription in alveolar macrophages. There are no previous studies of the rs2274611 CTSL polymorphism, but a CTSL promoter SNP (rs3118869) has been associated with reporter gene expression in vitro [21].…”

Section: Discussionmentioning

confidence: 82%

Alveolar macrophage proteinase/antiproteinase expression in lung function and emphysema

Ishii

Abboud

Wallace

et al. 2013

European Respiratory Journal

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Alveolar macrophages play an important role in chronic obstructive pulmonary disease via production of matrix metalloproteinases (MMPs) and cathepsins as well as their inhibitors, tissue inhibitors of metalloproteinases and cystatin C. We hypothesised that expression levels of these molecules by alveolar macrophages at baseline and after stimulation would be influenced by genotype and associated with chronic obstructive pulmonary disease phenotypes.Quantitative PCR and ELISAs/gelatine zymography were used to investigate expression levels of mRNA and protein, respectively. The relationships of expression with genotype, pulmonary function and emphysema were analysed.The results showed that basal expression level of MMP12 mRNA was inversely related to the diffusing capacity of the lung for carbon monoxide/alveolar volume and to forced expiratory volume in 1 s/forced vital capacity after correction for multiple comparisons. The expression level of MMP12 protein stimulated with lipopolysaccharide was also inversely related to the diffusing capacity of the lung for carbon monoxide/ alveolar volume and was positively related to the extent of emphysema. The basal expression of MMP1 mRNA was positively correlated with the extent of emphysema. Cathepsin L protein level was positively associated with forced expiratory volume in 1 s % predicted.We conclude that increased MMP12 and MMP1 expression may play a role in the pathogenesis of emphysema. Cathepsin L and MMP9 may be involved in the development of airflow limitation. @ERSpublications MMP12 expression may play a role in the pathogenesis of emphysema and airflow limitation

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Section: Discussionmentioning

confidence: 82%

Alveolar macrophage proteinase/antiproteinase expression in lung function and emphysema

Ishii

Abboud

Wallace

et al. 2013

European Respiratory Journal

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“…MMP1, an interstitial collagenase, degrades fibrillar collagens type Ⅰ, Ⅱ, Ⅲ, Ⅴ, Ⅸ, and Ⅹ, that form the most abundant class of extracellular matrix proteins in the interstitium [86] . The MMP1 gene is located on chro mosome 11q22.…”

Section: Colorectal Cancermentioning

confidence: 99%

Single-nucleotide polymorphisms of matrix metalloproteinases and their inhibitors in gastrointestinal cancer

Langers

Verspaget²,

Hommes³

et al. 2011

WJGO

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Matrix metalloproteinases (MMPs) are implicated in cancer development and progression and are associated with prognosis. Single-nucleotide polymorphisms (SNPs) of MMPs, most frequently located in the promoter region of the genes, have been shown to influence cancer susceptibility and/or progression. SNPs of MMP-1, -2, -3, -7, -8, -9, -12, -13 and -21 and of the tissue inhibitor of metalloproteinases (TIMPs) TIMP-1 and TIMP-2 have been studied in digestive tract tumors. The contribution of these polymorphisms to the cancer risk and prognosis of gastrointestinal tumors are reviewed in this paper.

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“…Genes encoding MMP-1, MMP-3, PAI-2 (SERPIN B2) and cathepsin all play a role in matrix degradation (20)(21)(22)(23). MET-tyrosine kinase and Fli-1 have already been described as Ets-1 target genes in human gastric cancer and in endothelial cells, respectively (24,25).…”

Section: Discussionmentioning

confidence: 99%

Identification of ETS-1 target genes in human fibroblasts

Hahne¹,

Okuducu²,

Fuchs³

et al. 2011

Int J Oncol

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Abstract. The transcription factor Ets-1 plays several distinct critical roles in tumour development and progression by acting both in neoplastic cells and in the tumour stroma. Increased expression of Ets-1 in tumours is often associated with a worse prognosis. Stromal fibroblasts attribute an important part to the behaviour of malignant tumours. In this study we investigated the role of Ets-1 in the tumour stroma. It is well known that ets-1 expression in fibroblasts -one of the main components of the tumour stroma -can be induced by basic fibroblast growth factor (bFGF). We applied suppression subtractive hybridization (SSH) to identify genes that are differentially expressed between bFGF stimulated wild-type fibroblasts and fibroblasts with reduced Ets-1 expression. We selected clones up-or down-regulated in bFGF stimulated wild-type fibroblasts using SSH and functionally characterized them by reference to public databases using NCBI BLAST tools. Expression levels of genes corresponding to subtracted clones were analyzed using RT-PCR. Known genes were associated with diverse functions; novel Ets-1 regulated genes identified by SSH not only encoded components involved in matrix degradation (as cathepsin and PAI-2) but also constituents of the extracellular matrix (ECM) including α-2-Type I collagen, TGF-β induced protein, lumican and decorin. Our findings identify several potential novel target genes of Ets-1, and they provide potentially important insights into the role of Ets-1 in stromal fibroblasts for both remodelling and different functionalities of the ECM.

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MMP-1 polymorphism and its relationship to pathological processes

Cited by 64 publications

References 56 publications

Alveolar macrophage proteinase/antiproteinase expression in lung function and emphysema

Alveolar macrophage proteinase/antiproteinase expression in lung function and emphysema

Single-nucleotide polymorphisms of matrix metalloproteinases and their inhibitors in gastrointestinal cancer

Identification of ETS-1 target genes in human fibroblasts

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