MMP-1 and MMP-8 expression in giant-cell fibroma and inflammatory fibrous hyperplasia

Oliveira, Henrique Climeck de; Tschoeke, André; Cruz, Gabriele Claudino da; Noronha, Lúcia de; Scariot, Rafaela; Mesquita, Ricardo Alves; Aguiar, Maria Cássia Ferreira de; Caldeira, Patrícia Carlos; Ribas, Marina de Oliveira; Grégio, Ana Maria Trindade; Azevedo‐Alanis, Luciana Reis; Ignácio, Sérgio Aparecido; Santos, Jean Nunes dos; Lima, Antônio Adilson Soares de; Johann, Aline Cristina Batista Rodrigues

doi:10.1016/j.prp.2016.10.002

Cited by 8 publications

(2 citation statements)

References 28 publications

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“…Another marked feature of IFH is the presence of significant amounts of collagen fibre bundles in connective tissue [20] as a result of an increase in fibroblast numbers, since these cells produce the extracellular matrix, that means an excessive deposition of collagen and increase in the clinical volume of these lesions [29]. Observing the data obtained in this study, histopathological findings are confirmed by deposition of collagen fibres replacing the connective tissue.…”

Section: Discussionsupporting

confidence: 71%

Evaluation of inflammatory processes by FTIR spectroscopy

Rodrigues

Carvalho

Bonnier

et al. 2018

Journal of Medical Engineering & Technology

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Fourier transform infrared (FTIR) spectroscopy is a powerful diagnosis technique and has been used to identify patterns of molecular changes based on vibration modes. The objective of this study was to evaluate inflammatory fibrous hyperplasia (IFH) lesions and oral normal mucosa (NM) initially with histopathological exam and then using micro-FTIR spectroscopy to analyse the samples. Eleven IFH and 11 NM samples were analysed at five different points to cover the largest area possible by the micro-FTIR technique. Bands were observed between 970 and 1743 cm which corresponded to different structural components like collagen, lipids, fatty acids, proteins and amino acids. Spectral bands were more intense mostly for IFH lesions, including collagen bands, which are an important component of inflammatory fibrous hyperplasia. This study demonstrated that differentiation in the inflammatory tissue was observed in FTIR spectral differences, in terms of biochemical composition.

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