The role of W -exchange diagrams in baryonic B decays is poorly understood, and often taken as insignificant. We show that charmful two-body baryonic B → B cB ′ decays, where B c is an antitriplet or a sextet charmed baryon, andB ′ an octet charmless (anti-)baryon, provide a good test-bed for the study of the W -exchange topology, whose contribution is found to be non-negligible. Thehence is naturally suited for the study of the role of the W -exchange topology. We predict B(B 0 s → Λ + cp ) = (1.2 +0.7 −0.5 ) × 10 −6 , a relatively large branching ratio to be tested with a future measurement by the LHCb collaboration. Other predictions, such as B(B 0 → Ξ + cΣ − ) = (1.8 +1.0 −0.8 ) × 10 −5 , can be tested with future Belle II measurements. *