We show that a two-dimensional (2D) spin-polarised Fermi gas immersed in a 3D Bose-Einstein condensate (BEC) constitutes a very promising system to realise a px + ipy superfluid. The fermions attract each other via an induced interaction mediated by the bosons, and the resulting pairing is analysed with retardation effects fully taken into account. This is further combined with BerezinskiiKosterlitz-Thouless (BKT) theory to obtain reliable results for the superfluid critical temperature. We show that both the strength and the range of the induced interaction can be tuned experimentally, which can be used to make the critical temperature approach the maximum value allowed by general BKT theory. Moreover, this is achieved while keeping the Fermi-Bose interaction weak so that three-body losses are small. Our results show that realising a topological superfluid with atomic Fermi-Bose mixtures is within experimental reach.The quest for realising topological phases of matter is presently a very active research topic [1,2]. Topological superconductors/superfluids are of particular interest, as they exhibit Majorana edge modes with possible applications for quantum computing [3]. In condensed matter systems, experimental evidence for Majorana modes have been reported in a number of one-dimensional materials [4][5][6][7][8][9][10]. Furthermore, Sr 2 RuO 4 is believed to realise a 2D topological superconductor [11][12][13][14]. However, it is highly desirable to find other systems which allow for unambiguous realisation of a topological superfluid. Cold atomic gases are attractive candidates for this task, as they are devoid of impurities and are highly controllable. Fermi gases interacting via a p-wave resonance have been suggested to realise topological superfluids [15], but they are found to have very short lifetimes [16][17][18][19]. Other suggestions using quantum gases include proposals based on optical lattices [20][21][22][23], synthetic spin-orbit coupling [24][25][26], driven dissipation [27,28], dipolar molecules [29] and mixed dimension Fermi-Fermi mixtures [30]. However, none of these proposals have been implemented experimentally so far, partly due to the prohibitively low superfluid critical temperatures in these systems.In this paper we show that a 2D-3D Fermi-Bose mixture can realise a p x + ip y topological superfluid with a high critical temperature. Spin-polarised fermions are confined to a 2D plane and interact via an attractive induced interaction mediated by density fluctuations in a weakly interacting 3D BEC. The superfluid transition of the 2D Fermi gas is investigated by first solving the mean-field gap equation, which has the Eliashberg form due to the frequency dependence of the induced interaction. Here the retardation effects are fully included and are found to be important. The superfluid density is then calculated and the critical temperature of the transition determined using BKT theory. To our knowledge, such a microscopic theory for the pairing of a Fermi gas based on a combination of El...