Mm of normal or cancerous laryngeal cartilages: Histopathologic correlation

Castelijns, Jonas A.; Gerritsen, G. J.; Kaiser, M. C.; Valk, J.; Jansen, Wicher; Meyer, C. J. L. M.; Snow, Gordon B.

doi:10.1288/00005537-198709000-00016

Cited by 36 publications

(6 citation statements)

References 15 publications

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“…Several studies have compared CT data [2-4, 25, 26, 36, 38], while a few studies have compared MRI data with the histology of whole-organ sections [6,9,10,40]. However, to our knowledge, no data are available comparing the results of endoscopic findings with CT and MRI and anatomically matched histologic whole organ sections analyzing the impact of each diagnostic method on pretherapeutic staging.…”

Section: Discussionmentioning

confidence: 99%

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Staging of laryngeal cancer: Endoscopy, computed tomography and magnetic resonance versus histopathology

Zbären

Becker

Läng³

1997

Eur Arch Otorhinolaryngol

108

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An accurate pretherapeutic staging of laryngeal cancer is required for optimal treatment planning and for evaluation and comparison of the results of different treatment modalities. In this study, 45 consecutive patients with neoplasms of the larynx, treated surgically, were included in a prospective pretherapeutic staging protocol that included indirect laryngoscopy, direct microlaryngoscopy, contrast-enhanced computed tomography (CT) and Gd-DTPA-enhanced magnetic resonance imaging (MRI). The surgical specimens were cut in whole-organ slices parallel to the plane of the axial CT and MR images. The histologic findings were then compared with clinical findings, CT and MRI. These findings showed that clinical evaluation failed to identify tumor invasion of the laryngeal cartilages and extralaryngeal soft tissues, resulting in a low staging accuracy (55%). Many pT4 tumors were clinically understaged. The combination of clinical/endoscopic evaluation and either CT or MRI resulted in a significantly improved staging accuracy (80% vs 87%, respectively). MRI was significantly more sensitive but less specific than CT in detecting neoplastic cartilage invasion. MRI tended to overestimate neoplastic cartilage invasion to possibly result in overtreatment, while CT was found to underestimate neoplastic cartilage invasion and could lead to inadequate therapeutic decisions.

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Section: Discussionmentioning

confidence: 99%

“…Based on the literature, MRI appears to be more suitable than CT in predicting neoplastic cartilage invasion [6,9,12,13,39]. However, it has still not been determined which imaging modality, CT or MRI, should be used in the pretherapeutic staging of laryngeal cancer.…”

Section: Introductionmentioning

confidence: 99%

Staging of laryngeal cancer: Endoscopy, computed tomography and magnetic resonance versus histopathology

Zbären

Becker

Läng³

1997

Eur Arch Otorhinolaryngol

108

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“…Having no threshold dose, the magnitude depends both on the volume of salivary tissue irradiated and dose of radiation delivered. Xerostomia and its associated symptoms have a considerable, negative global impact, resulting in shame, anxiety, disappointments and verbal communication difficulties [1][2][3]. Treatment of radiation induced xerostomia calls for good hydration, optimal oral hygiene and prophylaxis of candidiasis.…”

Section: Discussionmentioning

confidence: 99%

“…For cure, radiation doses more than 60Gy are needed though the tolerance of normal organs e.g. salivary gland varies between 32Gy (TD5/5) to 46Gy (TD50/5) [1]. Out of all the radiation reactions, xerostomia, the subjective sensation of dry mouth is one of the commonest and most troublesome.…”

Section: Introductionmentioning

confidence: 99%

Pilocarpine and Prevention of Radiation Induced Xerostomia in HNSCC

Atri¹

2014

JCPCR

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“…The use of Gd intravenous contrast material further refines detection (89). Cartilage invasion, carotid encasement, and transglottic involvement via submucosal spread are also well studied with MR scanning (27, 88, 90). Because spiral CT is readily available and scanning times are extremely rapid, CT remains a valuable and frequently used screening modality for the larynx (Table 1, Fig.…”

Section: Appropriate Applicationsmentioning

confidence: 99%

Head and neck imaging: The role of CT and MRI

Wippold

2007

Magnetic Resonance Imaging

119

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High-resolution computed tomography (CT) and magnetic resonance imaging (MRI) have become indispensable tools for the evaluation of conditions involving the head and neck. Complex anatomic structures and regions, such as the orbit, skull base, paranasal sinuses, deep spaces of the neck, larynx, and lymph nodes, require that the radiologist be familiar with the imaging modalities available and their appropriate applications. The purpose of this article is to review the techniques of CT and MRI and the roles they play in clinical practice, including head and neck disorders. THE RAPIDLY EXPANDING INTEREST in the neck has been largely fueled by the tremendous technical development and availability of cross-sectional imaging, and by the appreciation of these advancements by our clinical colleagues. High-resolution rapid computed tomography (CT) and magnetic resonance imaging (MRI) have long since proven themselves sensitive and reliable in appropriate applications (1,2). Indeed, imaging has become an indispensable tool in the characterization and staging of conditions involving the head and neck, and clinicians have come to incorporate imaging data with physical examinations and endoscopy. CT and MRI not only provide essential information about the deep extension of clinically detected masses, they can also delineate additional clinically unsuspected lesions. The excellent tissue characterization of MR scans can lead to an accurate diagnosis of many benign processes as well. A complete study of head and neck imaging is beyond the scope of this article; however, a review of some of the applications of CT and MRI may be helpful. KEY CONCEPTSSeveral key concepts must be applied when considering cross-sectional imaging in the evaluation of head and neck lesions. First of all, imaging is a tool that supplements and complements the physical examination. Cross-sectional imaging is not a "stand-alone" procedure. Second, CT and MRI emphasize anatomy and the changes in anatomy that occur with pathology. Therefore, knowledge of head and neck anatomy is crucial for the accurate interpretation of images. Third, CT and MRI complement each other. Certain processes are better studied with one method than the other, and the various applications, strengths, and weaknesses of each modality should be carefully considered. Fourth, "context is king." The interpretation of imaging studies should take into account the patient's history, physical findings, comorbidities, and previous procedures that may influence the structures visualized. Comparison films and previous imaging reports are also extremely useful and enable the imager to understand the clinical issues that prompted the scan request. Of course, old reports may be inaccurate and the radiologist should carefully verify the source of information. TECHNIQUES CT Standard Spiral CTCT scanning of the head and neck should be tailored for the anatomic region under consideration. A digital lateral scout radiograph may assist in planning the scan ranges. Spiral (helical) CT scanning is rap...

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Mm of normal or cancerous laryngeal cartilages: Histopathologic correlation

Cited by 36 publications

References 15 publications

Staging of laryngeal cancer: Endoscopy, computed tomography and magnetic resonance versus histopathology

Staging of laryngeal cancer: Endoscopy, computed tomography and magnetic resonance versus histopathology

Pilocarpine and Prevention of Radiation Induced Xerostomia in HNSCC

Head and neck imaging: The role of CT and MRI

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