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Microwave‐Assisted Synthesis of Novel Symmetric Bis‐1,2,4‐triazolin‐3‐ones as Potent Inhibitors of CYP51: An Antifungal Activity Study

“…Fluconazole was the first‐line bis‐triazole antifungal medicine suggested by World Health Organization (WHO) . In the current years, attention has been increasingly paid to the synthesis of bisheterocyclic compounds, which exhibit diverse biological activities . Some of the reported bis‐1,2,4‐triazole molecules represented in Figure viz., N,N‐{10‐bis[(1, 2,4 triazol‐1‐yl) methyl]}diéthylamino‐30‐propanamine 1 (anti‐microbial), 2 (antifungal), 5 bis (1,3,4‐triazole), 4 (anti‐oxidant), 5,5‐(1,4‐phenylene)bis(4‐phenyl‐3‐mercapto‐1,2,4‐triazole) 3 (antifungal) .…”

Synthesis and characterization of some new 4,4′-(1,4-phenylene)dipyrimidine and 6,6′-(1,4-phenylene)-di(pyridin-2(1H)-one) derivatives

“…In addition, bisheterocyclic compounds exhibit various biological activities [9][10][11][12] and exert much higher antibacterial activity than heterocyclic compounds [13,14]. However, a literature survey revealed only p-(4,4-dipyrimidinyl)-benzene [15], p-(4,4-di(4-hydroxypyrimidinyl)-benzene [16], and 1,4-bis-(2-pyridone-6-yl)-benzene [17] have been prepared, which require drastic conditions and complex pathways.…”

Preparation and properties of magnetic Fe3O4/poly(pyrimidine-amide) nanocomposites: selective polyamidation of a bis(amino-pyrimidine-diol) compound in an ionic liquid

“…15,16 The simultaneous presence of an azide group and an o-phenol moiety in a pyrimidine molecule is certainly of scientic and practical interest, since the formation of a strong intramolecular hydrogen bond between the phenolic hydroxyl and the aza atom of the heteroaromatic ring has an effect on the reactivity. 17 The unique magnetic properties of Fe 3 O 4 nanoparticles and its composites have led to their implementation in many technological as well as biomedical applications in a wide variety of elds such as data storage, catalysis, gas sensors, magnetic resonance imaging, wastewater remediation, bioseparation, medicine etc. [18][19][20] The magnetic nanoparticles tend to form agglomerates by interaction among themselves or with biological molecules and precipitate out of the system.…”