Abstract:statement 26 The H3K4 methyltransferases MLL3 and MLL4 have strikingly different null 27 phenotypes during mouse development; MLL3 is required for lung maturation 28 whereas MLL4 is required for anterior visceral endoderm migration. 29 30 Abstract 31 Methylation of histone 3 lysine 4 (H3K4) is a major epigenetic system 32 associated with gene expression. In mammals there are six H3K4 33 methyltransferases related to yeast Set1 and fly Trithorax, including two 34 orthologs of fly Trithorax-related: MLL3 and MLL… Show more
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