MLL/ENL fusion in congenital acute lymphoblastic leukemia wiith a unique t(11;18;19)

Horstmann, Martin; Argyriou-Tirita, Anthi; Kabisch, H; Kapaun, Petra; Winkler, Kurt; Haas, Oskar A.

doi:10.1016/0165-4608(95)00276-6

Cited by 12 publications

(3 citation statements)

References 34 publications

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“…Two patients had complex t(11;19)(q23;p13.3) translocations, and both were diagnosed with pro-B ALL: (1) One patient (618) had a three-way translocation, t(11;18;19)(q23;q22;p13.3) and has been previously published as a case study. 20 FISH, using a MLL probe and wcps to chromosomes 11, 18 and 19, confirmed the translocation and showed that MLL was split between chromosomes 11 and 18. The derivative, der(11)t(11;19) with MLL-ENL fusion was retained as confirmed by RT-PCR.…”

Section: Survivalmentioning

confidence: 93%

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The translocations, t(11;19)(q23;p13.1) and t(11;19)(q23;p13.3): a cytogenetic and clinical profile of 53 patients

et al. 1998

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The EU Concerted Action Workshop on 11q23 Abnormalities in Hematological Malignancies collected 550 patients with abnormalities involving 11q23. Of these, 53 patients had a translocation involving chromosome 11, breakpoint q23, and chromosome 19, breakpoint p13. Karyogram review enabled each patient to be further defined as t(11;19)(q23;p13.1) (21 patients) or t(11;19)(q23;p13.3) (32 patients). There was a marked difference between the type of banding and the translocation identified: t(11;19)(q23;p13.1) was detected predominantly by R-banding, whereas t(11;19)(q23;p13.3) was detected almost solely by G-banding. Additional change was extremely rare in patients with t(11;19)(q23;p13.1) but occurred in nearly half of the patients with t(11;19)(q23;p13.3). Patients with t(11;19)(q23;p13.1) all had leukemia of a myeloid lineage, mostly acute myeloid leukemia (AML), and were predominantly adult. In contrast patients with t(11;19)(q23;p13.3) had malignancies of both myeloid and lymphoid lineage and were mainly infants less than 1 year old. The survival of both groups of patients was generally poor, over 50% of t(11;19)(q23;p13.1) patients died within 2 years of diagnosis and the median survival of acute lymphoblastic leukemia (ALL) patients with t(11;19)(q23;p13.3) was 17.6 months.

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Section: Survivalmentioning

confidence: 93%

“…16 Karyograms of each patient had been reviewed and the translocations, t (11;19) 20 Statistical analyses were performed as described by Secker-Walker. 16 Results t(11;19)(q23;p13.1) -see Table 1 Cytogenetics, FISH, reverse transcriptase polymerase chain reaction (RT-PCR) and Southern blotting:…”

Section: Methodsmentioning

confidence: 99%

The translocations, t(11;19)(q23;p13.1) and t(11;19)(q23;p13.3): a cytogenetic and clinical profile of 53 patients

et al. 1998

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“…In most cases, the MLLT1 gene is rearranged with the MLL gene via a balanced reciprocal translocation, but also more complex aberrations have been described including three way translocations. [5][6][7] The t(11;19)(q23;p13.3) has been identified in patients with lymphoid, myeloid and biphenotypic malignancies. Therapy-related translocations between MLL and MLLT1 are very rare, and so far only one t-AML case has been described in the literature.…”

mentioning

confidence: 99%

Spliced MLL fusions: a novel mechanism to generate functional chimeric MLL-MLLT1 transcripts in t(11;19)(q23;p13.3) leukemia

et al. 2007

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Complex and cryptic chromosomal rearrangements involving the MLL gene in acute leukemia: A study of 7 patients and review of the literature

Braekeleer

Meyer

Douet‐Guilbert

et al. 2010

Blood Cells, Molecules, and Diseases

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MLL/ENL fusion in congenital acute lymphoblastic leukemia wiith a unique t(11;18;19)

Cited by 12 publications

References 34 publications

The translocations, t(11;19)(q23;p13.1) and t(11;19)(q23;p13.3): a cytogenetic and clinical profile of 53 patients

The translocations, t(11;19)(q23;p13.1) and t(11;19)(q23;p13.3): a cytogenetic and clinical profile of 53 patients

Spliced MLL fusions: a novel mechanism to generate functional chimeric MLL-MLLT1 transcripts in t(11;19)(q23;p13.3) leukemia

Complex and cryptic chromosomal rearrangements involving the MLL gene in acute leukemia: A study of 7 patients and review of the literature

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