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Abstract

It is a cross-sectional study, comparing the prevalence of Helicobacter pylori infection (prevalence of IgG antibodies to H. pylori) in the healthy population of Ubrique and Grazalema (mountain location, mortality from stomach cancer 20/100,000) and in Barbate, (coastal location, mortality from stomach cancer 10/100,000) in the province of Cadiz, southern Spain. The subjects were randomly selected, 163 men and 169 women, 18 years or older; 179 persons were studied in the inland, and 154 in the littoral in January 1997. Of the 332 subjects investigated, 43% were positive, a mean antibody titer of 337 IU/1 (95 % CI: 254-420), and 56% were negative, with a mean titer of 18 IU/1 (95% CI: 15-19). In the coastal population, 30% has positive titers and 54% in the mountain location. By age: 18-40 years, 30% of littoral and 41% of inland population had positive titers; 41-60 years, 35% of those living in the littoral and 58% of inland population had positive titers; > 60 years, 24% of coastal inhabitants and 62% of those living in the inland had positive titers. Living in mountain locations in the province of Cadiz involves a greater ecological risk for H. pylori infection (p < 0.05).

Gastric cancer mortality trends in Spain, 1976-2005, differences by autonomous region and sex

“…Some factors, such as the role of H. pylori as a carcinogenic promoter [26], or diet [27,28], which contribute to the etiopathogeny of GC are widely accepted. In Spain, studies published on the prevalence of H. pylori infection report interregional differences ranging from 43% [29] to 69% [30], but the scarcity of data do not enable their implication in the trend in rates to be assessed.…”

“…Some factors, such as the role of H. pylori as a carcinogenic promoter [26], or diet [27,28], which contribute to the etiopathogeny of GC are widely accepted. In Spain, studies published on the prevalence of H. pylori infection report interregional differences ranging from 43% [29] to 69% [30], but the scarcity of data do not enable their implication in the trend in rates to be assessed. Insofar as diet is concerned, some risk factors, e.g., intake of nitrates through consumption of cured and pickled foods [31,32] or drinking water [33,34], and prevention factors, e.g., consumption of fruit and vegetables in particular, have been recognized.…”

Concurrent overexpression of serum p53 mutation related with Helicobacter pylori infection

“…As quantitative variables we recorded serum level of H. pylori IgG-specific antibody, expressed as IU/L [2,35], serum level of p53, expressed as ng/mL, and serum concentration of ceruloplasmin, expressed as mg/L [36]. As a nominal variable we recorded whether the subject was a resident of Barbate or Ubrique.…”

“…In the southern Atlantic province of Cadiz, coastal towns such as Barbate have an adjusted mortality rate of 10/100.000 inhabitants, whereas towns such as Ubrique, located in the mountainous region 30 kilometers inland, have an adjusted mortality rate of 20/100.000 [2]. An earlier study found that the rate of Helicobacter pylori infection (determined by measuring serum H. pylori IgG antibodies) in the normal population was 54% in Ubrique, but only 32% in Barbate, where the mortality rate for stomach cancer is lower.…”

“…An earlier study found that the rate of Helicobacter pylori infection (determined by measuring serum H. pylori IgG antibodies) in the normal population was 54% in Ubrique, but only 32% in Barbate, where the mortality rate for stomach cancer is lower. Mean antibody titers are also higher in the area with the higher mortality rate [2]. …”