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Rensburg, Susan J. van; Daniels, Willie M. U.; Zyl, Johann M. van; Taljaard, J. J. F.

doi:10.1023/a:1011167023695

Cited by 88 publications

(23 citation statements)

References 14 publications

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“…In addition to their cholesterol lowering effect, plant sterols may possess anti-atherosclerosis [32,33], antibacterial [36], anti-inflammation [34] and anti-oxidation activities [35]. In the present study, β-sitosterol ( 4 ) and the mixture of sterols [campesterol ( 2 ), stigmasterol ( 3 ) and β-sitosterol ( 4 )] did not display cytotoxic effects against the tested cell lines.…”

Section: Resultsmentioning

confidence: 60%

Cytotoxic Components of Pereskia bleo (Kunth) DC. (Cactaceae) Leaves

et al. 2009

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Dihydroactinidiolide (1) and a mixture of sterols [campesterol (2), stigmasterol (3) and β-sitosterol (4)], together with the previously isolated individual compounds β-sitosterol (4), 2,4-di-tert-butylphenol (5), α-tocopherol (6), phytol (7) were isolated from the active ethyl acetate fraction of Pereskia bleo (Kunth) DC. (Cactaceae) leaves. Cytotoxic activities of the above mentioned compounds against five human carcinoma cell lines, namely the human nasopharyngeal epidermoid carcinoma cell line (KB), human cervical carcinoma cell line (CasKi), human colon carcinoma cell line (HCT 116), human hormone-dependent breast carcinoma cell line (MCF7) and human lung carcinoma cell line (A549); and non-cancer human fibroblast cell line (MRC-5) were investigated. Compound 5 possessed very remarkable cytotoxic activity against KB cells, with an IC50 value of 0.81µg/mL. This is the first report on the cytotoxic activities of the compounds isolated from Pereskia bleo.

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Section: Resultsmentioning

confidence: 60%

Cytotoxic Components of Pereskia bleo (Kunth) DC. (Cactaceae) Leaves

et al. 2009

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“…They are tri-terpenes with a wide spectrum of biological activities in animals and humans, including anti-inflammatory,[45] anti-bacterial,[46] antioxidative[47] and anti-cancerous. [48] Different groups of phytosterols include sitosterol, campesterol, stigmasterol, Δ 5 -avenasterol, sitostanol and campestanol.…”

Section: Diversity In Improved Varieties and Wild Speciesmentioning

confidence: 99%

Value addition in sesame: A perspective on bioactive components for enhancing utility and profitability

Pathak¹,

K²,

Kumari³

et al. 2014

Phcog Rev

215

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Sesame seed is a reservoir of nutritional components with numerous beneficial effects along with health promotion in humans. The bioactive components present in the seed include vital minerals, vitamins, phytosterols, polyunsaturated fatty acids, tocopherols and unique class of lignans such as sesamin and sesamolin. The presence of phenylpropanoid compounds namely lignans along with tocopherols and phytosterols provide defense mechanism against reactive oxygen species and increases keeping quality of oil by preventing oxidative rancidity. In this article, we have reviewed the nutraceutical, pharmacological, traditional and industrial value of sesame seeds with respect to bioactive components that hold high antioxidant value. Valuable information on superior functional components of sesame will strongly promote the use of sesame seeds in the daily diet world-wide. In spite of huge repertoire of sesame germplasm collection, limited research efforts on the use of conventional and biotechnological methodologies have resulted in minimal success in developing nutritionally superior cultivars. In consequence, value addition efforts in sesame would enable development of genotypes with high antioxidant activity and subsequently prevention of free radical related diseases. Modification of bioactive components in sesame would enable production of stabilized sesame oil with enhanced shelf life and better market value.

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“…In addition to the mentioned blood cholesterol-lowering effect, phytosterols have shown the following activities in animals: anti-cancer properties (with a beneficial effect upon the inhibition of colon cancer development) [17][18][19][20], and antiatherosclerotic [21], anti-inflammatory [22] and anti-oxidative effects [23].…”

Section: Physiological Functions Of Phytosterolsmentioning

confidence: 99%

Analysis of phytosterols in foods

Lagarda

García‐Llatas

Farré

2006

Journal of Pharmaceutical and Biomedical Analysis

277

208

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Phytosterols are bioactive compounds, one of their most studied and outstanding properties being their cholesterol-lowering activity. This explains the growing interest in the phytosterol contents of foods as either intrinsic or added components. The different steps (extraction, saponification, clean up, chromatographic determination) of plant sterol determination are reviewed, and emphasis is placed on the methods used to assay different phytosterols in food.

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Untitled

Cited by 88 publications

References 14 publications

Cytotoxic Components of Pereskia bleo (Kunth) DC. (Cactaceae) Leaves

Cytotoxic Components of Pereskia bleo (Kunth) DC. (Cactaceae) Leaves

Value addition in sesame: A perspective on bioactive components for enhancing utility and profitability

Analysis of phytosterols in foods

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