MKK7 Is A Stress-activated Mitogen-activated Protein Kinase Kinase Functionally Related to hemipterous

Holland, Pamela M.; Suzanne, Magali; Campbell, Jean S.; Noselli, Stéphane; Cooper, Jonathan A.

doi:10.1074/jbc.272.40.24994

Cited by 175 publications

(136 citation statements)

References 28 publications

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“…MKK4 activates both JNK and p38 MAPK (Derijard et al, 1995;Han et al, 1996;Jiang et al, 1996;Lin et al, 1995;Sanchez et al, 1994), while MKK7 selectively activates JNK (Holland et al, 1997;Lu et al, 1997;Moriguchi et al, 1997;Tournier et al, 1997Tournier et al, , 1999. In this study, we clari®ed that MKK7 but not MKK4 was involved in the process of IR-induced and PKC d-dependent JNK activation.…”

Section: Discussionmentioning

confidence: 70%

PKC δ mediates ionizing radiation-induced activation of c-Jun NH2-terminal kinase through MKK7 in human thyroid cells

et al. 2001

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The thyroid gland is one of the most sensitive organs in ionizing radiation (IR)-induced carcinogenesis. To determine, therefore, the speci®c cascade of IR-induced signal transduction in human thyroid cells, we investigated the functional role of protein kinase C (PKC), especially its interlocking activation of c-Jun NH 2 -terminal kinase (JNK) pathway. In the present study, using adenovirus expression vectors for diverse dominant-negative (

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Section: Discussionmentioning

confidence: 70%

PKC δ mediates ionizing radiation-induced activation of c-Jun NH2-terminal kinase through MKK7 in human thyroid cells

et al. 2001

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“…JNKs are activated by two distinct MAPKKs, MKK4/SEK1 (Sanchez et al, 1994;Derijard et al, 1995), and MKK7 Yao et al, 1997;Wu et al, 1997;Tournier et al, 1997;Holland et al, 1997), in the JNK signaling unit. The p38 subgroup is composed of four genes including p38a, p38b, p38g and p38d (Han et al, 1994;Lee et al, 1994;Jiang et al, 1997;Stein et al, 1997;Goedert et al, 1997;Wang et al 1997).…”

Section: Upstream Kinases In the Jnk And P38 Modulesmentioning

confidence: 99%

From receptors to stress-activated MAP kinases

1999

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The cell signaling pathways that culminate in activation of a family of stress-activated MAP kinases are beginning to be de®ned. Determination of cell life and cell death is known to largely depend on the balance of intrinsic life and death signals within cells. Recently, two representative mammalian stress-activated kinases, the JNK and p38 MAP kinases, have been implicated in determination of cell fate by modifying the life, death and di erentiation signals. However, the molecular mechanisms by which extracellular signals are transmitted from membrane receptors to the most upstream kinases in the JNK and p38 signaling modules are not fully understood. This review will provide an overview of current knowledge of molecular links between in¯amma-tory cyokine receptors and stress-activated MAP kinase cascades.

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“…One of the ®rst events is thought to be activation of the JNK signaling pathway in the LE cells. Members of the core JNK signaling module that have been cloned in Drosophila include hemipterous (hep), a JNKK and functional homolog of mammalian MKK7, basket (bsk), a JNK, and DJun Holland et al, 1997;Hou et al, 1997;Kockel et al, 1997;RiesgoEscovar et al, 1996;Sluss et al, 1996). Mutations in each gene lead to embryos with severe dorsal and anterior open cuticles indicative of a failure of DC and head involution.…”

Section: Introductionmentioning

confidence: 99%