MK212, a 5-hydroxytryptamine 2C receptor agonist, reverses prepulse inhibition deficits in the medial prefrontal cortex and ventral hippocampus

Guo, Guanlong; Tang, Jiaxin; Shi, Meng-Wen; Yang, Chung‐Yi; Ou, Huaxing; Chen, Weihai

doi:10.1016/j.pnpbp.2021.110441

Cited by 2 publications

(1 citation statement)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, 5-HT 2c receptors could also be involved in the PPI deficits caused by adolescent JWH-018 exposure. Indeed, the activation of this serotonin receptor has been previously shown to reverse PPI deficits induced by apomorphine in rats [ 67 ], and by the NMDA antagonist MK801 in mice [ 68 ]. Moreover, we observed a decrease in the mRNA levels of 5-HT 2c receptor in the prefrontal cortex of adolescent male mice exposed to JWH-018 in the short-term (data not shown), a mechanism that will be worth exploring in the future.…”

Section: Discussionmentioning

confidence: 99%

Adolescent exposure to the Spice/K2 cannabinoid JWH-018 impairs sensorimotor gating and alters cortical perineuronal nets in a sex-dependent manner

Izquierdo-Luengo,

Ten-Blanco,

Ponce-Renilla

et al. 2023

Transl Psychiatry

View full text Add to dashboard Cite

The consumption of synthetic cannabinoids during adolescence is reported to be a risk factor for the appearance of psychiatric disorders later in life. JWH-018 was identified as one of the primary psychoactive components present in Spice/K2 preparations. This study evaluated the short- and long-term consequences of exposure to JWH-018 during the adolescence in anxiety-like behavior, fear extinction, and sensorimotor gating in male and female mice. Alterations in anxiety varied depending on the time interval between treatment and behavioral analysis along with sex, while no changes were observed in the extinction of fear memory. A decrease in prepulse inhibition of the startle reflex was revealed in male, but not female, mice at short- and long-term. This behavioral disturbance was associated with a reduction in the number of perineuronal nets in the prelimbic and infralimbic regions of the prefrontal cortex in the short-term. Furthermore, adolescent exposure to JWH-018 induced an activation of microglia and astrocytes in the prefrontal cortex of male mice at both time intervals. A transitory decrease in the expression of GAD67 and CB2 cannabinoid receptors in the prefrontal cortex was also found in male mice exposed to JWH-018. These data reveal that the treatment with JWH-018 during the adolescence leads to long-lasting neurobiological changes related to psychotic-like symptoms, which were sex-dependent.

show abstract

Section: Discussionmentioning

confidence: 99%